Nice and slow make the germinal centers go: measured and escalating antigen delivery enhance durability and quality of humoral immune responses against HIV-1.

Tan, Hyon-Xhi; Davenport, Miles P; Kent, Stephen J; Wheatley, Adam K

Tan, Hyon-Xhi; Davenport, Miles P; Kent, Stephen J; Wheatley, Adam K.

Tan HX; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Davenport MP; Kirby Institute, University of New South Wales, Kensington, NSW, Australia.
Kent SJ; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Wheatley AK; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia.

Immunol Cell Biol ; 100(10): 750-752, 2022 11.

Article in English | MEDLINE | ID: covidwho-2113212

ABSTRACT

ABSTRACT

A recently published article has confirmed that a novel immunization method of sustained and escalating antigen delivery augments the magnitude, quality and durability of humoral immune responses.

Subject(s)

HIV-1; Immunity, Humoral; Germinal Center; Antigens; Immunization

Keywords

Escalating dose; humoral responses; immunization

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV-1 / Immunity, Humoral Language: English Journal: Immunol Cell Biol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: Imcb.12596

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