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Pre COVID-19 molecular epidemiology of respiratory syncytial virus (RSV) among children in Bangladesh.
Hossain, Mohammad Enayet; Rahman, Mohammed Ziaur; Islam, Md Muzahidul; Hoque, Ananya Ferdous; Sumiya, Mariya Kibtiya; Begum, Mst Noorjahan; Alam, Mohammad Mamun; Uddin, K M Main; Hassan, Md Zakiul; Rahman, Mustafizur; Goswami, Doli Rani; Brooks, W Abdullah.
  • Hossain ME; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Rahman MZ; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Islam MM; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Hoque AF; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Sumiya MK; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Begum MN; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Alam MM; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Uddin KMM; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Hassan MZ; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Rahman M; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Goswami DR; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
  • Brooks WA; icddr,b, Infectious Diseases Division, Dhaka, Bangladesh.
Heliyon ; 8(10): e11043, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2113687
ABSTRACT
Epidemiological data of specific respiratory pathogens from the pre-COVID-19 period are essential to determine the effects of the COVID-19 pandemic on other respiratory infections. In this study, we revealed the pre-COVID-19 molecular epidemiology of respiratory syncytial virus (RSV) among children in Bangladesh. We tested 3170 samples collected from 2008 to 2012 for a panel of respiratory viruses; RSV, human metapneumovirus (hMPV), human parainfluenza viruses (hPIV) 1, 2, 3, and adenovirus. Five hundred fifty-five samples (17.5 %) were positive for RSV, including 2.5% having co-infections with other viruses. Genotypic characterization of RSV showed that RSV-A (82%) contributed more acute respiratory infections than RSV-B (18%). Clinical features were similar with RSV-A and RSV-B infections. However, children with RSV-B were more likely to have upper respiratory infections (URI) (10% vs. 29%, p = 0.03). Among RSV-A cases, hospitalization was higher for ON1 cases (25%, ON1 vs. 8%, NA1, p = 0.04), whereas the recovery without a disability was higher among the NA1 cases (56%, ON1 vs. 88%, NA1, p = 0.02). The time to the most recent common ancestor (TMRCA) for RSV in Bangladesh was 1949 for RSV-A and 1944 for RSV-B. This study revealed the genotypic diversity and evolutionary relatedness of RSV strains in Bangladesh and provided pre-COVID molecular epidemiology data to understand better the COVID-19 impact on upcoming RSV epidemiology in Bangladesh.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Heliyon Year: 2022 Document Type: Article Affiliation country: J.heliyon.2022.e11043

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Heliyon Year: 2022 Document Type: Article Affiliation country: J.heliyon.2022.e11043