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SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case.
Nakamura, Yoshihiko; Katano, Harutaka; Nakajima, Noriko; Sato, Yuko; Suzuki, Tadaki; Sekizuka, Tsuyoshi; Kuroda, Makoto; Izutani, Yoshito; Morimoto, Shinichi; Maruyama, Junichi; Koie, Megumi; Kitamura, Taisuke; Ishikura, Hiroyasu.
  • Nakamura Y; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: pdmxy@yahoo.co.jp.
  • Katano H; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. Electronic address: katano@nih.go.jp.
  • Nakajima N; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. Electronic address: tenko@nih.go.jp.
  • Sato Y; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. Electronic address: kiyonaga@nih.go.jp.
  • Suzuki T; Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. Electronic address: tksuzuki@nih.go.jp.
  • Sekizuka T; Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. Electronic address: sekizuka@nih.go.jp.
  • Kuroda M; Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan. Electronic address: makokuro@nih.go.jp.
  • Izutani Y; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: nrk14110@yahoo.co.jp.
  • Morimoto S; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: otomirom7960@yahoo.co.jp.
  • Maruyama J; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: marujun1025@icloud.com.
  • Koie M; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: m_33_skyline@yahoo.co.jp.
  • Kitamura T; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: taisuke@kitamura.or.jp.
  • Ishikura H; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. Electronic address: ishikurah@fukuoka-u.ac.jp.
Int J Infect Dis ; 111: 43-46, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-2113690
ABSTRACT
A 72-year-old patient was admitted to the intensive care unit due to acute respiratory distress syndrome caused by COVID-19. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3-V6 and severe left ventricular dysfunction with an ejection fraction of 35%-40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple organ failure. In post-mortem biopsy, SARS-CoV-2 antigen was detected in cardiomyocytes by immunostaining. Moreover, SARS-CoV-2 RNA was detected in heart tissue. We need to further analyse the direct link between SARS-CoV-2 and cardiomyocytes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Takotsubo Cardiomyopathy / COVID-19 Type of study: Case report Limits: Aged / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Takotsubo Cardiomyopathy / COVID-19 Type of study: Case report Limits: Aged / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article