Effects of Different Oncological Treatments on the Antibody Response to Covid19 Mrna Vaccine

ABSTRACT

Background: A satisfying development of antibody title after vaccine finds out his protagonist in immune system. In oncological patient immune system can be influenced by type of active treatment as Immunotherapy, Target therapy, Chemo therapy and its premedication with anti inflammatory steroids. This study aim to determine whether cancer medical treatment influenced antibody title response to Covid 19 mRNA vaccine. Material(s) and Method(s) We retrospectively analyzed 256 vaccinated patients with two doses of Covid19 mRNA vaccine, undergoing treatment with immuno chekpoint inhibitors, target therapy, chemo therapy, in our institution between february and july 2021. Total IgG and antiSpike protein anti SARS Covid 19 antibody title, a complete blood cell count and blood dosage of vitamine D have been determined at four weeks from the end of vaccination cycle. Differences in antiCovid19 antibody title has been evaluated and compared with t-student, test Wilcoxon Mann Whitney, Kilmogorov Smirnov among each subgroup of patients according to different types of treatment. Bivariate analysis has been performed in order to asses correlation between continous variables blood dosage of vitamine D, Neutrophils-lymphocyte-ratio (NLR) and antiSpike protein antibody title. Result(s) No statistically significant difference has been observed in total and antispike protein antibody title between subgroups according to type of oncological treatment. Bivariate analysis revealed a correlation between blood levels of vitamine D, NLR and antiSpike protein title reached. Conclusion(s) Different types of Oncological treatment as Immunotherapy, Target therapy and Chemotherapy do not influence the development of antibody title response to Covid19 mRNA vaccine;Vitamin D seems to have an important role to promote humoral immunity as well as NLR.