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Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases.
Cheng, Xiaomin; Zhang, Yali; Li, Yifan; Wu, Qin; Wu, Jiani; Park, Soo-Kyung; Guo, Cheng; Lu, Jiahai.
  • Cheng X; School of Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China.
  • Zhang Y; Guangzhou Nansha District Center for Disease Control and Prevention, Guangzhou, China.
  • Li Y; School of Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China.
  • Wu Q; School of Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China.
  • Wu J; School of Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China.
  • Park SK; School of Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China.
  • Guo C; Division of Gastroenterology, Department of Internal Medicine and Inflammatory Bowel Disease Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Lu J; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA. cg2984@cumc.columbia.edu.
BMC Microbiol ; 22(1): 274, 2022 11 14.
Article in English | MEDLINE | ID: covidwho-2115637
ABSTRACT

BACKGROUND:

Dozens of studies have demonstrated gut dysbiosis in COVID-19 patients during the acute and recovery phases. However, a consensus on the specific COVID-19 associated bacteria is missing. In this study, we performed a meta-analysis to explore whether robust and reproducible alterations in the gut microbiota of COVID-19 patients exist across different populations.

METHODS:

A systematic review was conducted for studies published prior to May 2022 in electronic databases. After review, we included 16 studies that comparing the gut microbiota in COVID-19 patients to those of controls. The 16S rRNA sequence data of these studies were then re-analyzed using a standardized workflow and synthesized by meta-analysis.

RESULTS:

We found that gut bacterial diversity of COVID-19 patients in both the acute and recovery phases was consistently lower than non-COVID-19 individuals. Microbial differential abundance analysis showed depletion of anti-inflammatory butyrate-producing bacteria and enrichment of taxa with pro-inflammatory properties in COVID-19 patients during the acute phase compared to non-COVID-19 individuals. Analysis of microbial communities showed that the gut microbiota of COVID-19 recovered patients were still in unhealthy ecostates.

CONCLUSIONS:

Our results provided a comprehensive synthesis to better understand gut microbial perturbations associated with COVID-19 and identified underlying biomarkers for microbiome-based diagnostics and therapeutics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / COVID-19 Type of study: Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: BMC Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: S12866-022-02686-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / COVID-19 Type of study: Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: BMC Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article Affiliation country: S12866-022-02686-9