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Wastewater-Based Surveillance Is an Effective Tool for Trending COVID-19 Prevalence in Communities: A Study of 10 Major Communities for 17 Months in Alberta.
Pang, Xiaoli; Gao, Tiejun; Ellehoj, Erik; Li, Qiaozhi; Qiu, Yuanyuan; Maal-Bared, Rasha; Sikora, Christopher; Tipples, Graham; Diggle, Mathew; Hinshaw, Deena; Ashbolt, Nicholas J; Talbot, James; Hrudey, Steve E; Lee, Bonita E.
  • Pang X; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
  • Gao T; Alberta Precision Laboratories, Edmonton, Alberta T6G 2J2, Canada.
  • Ellehoj E; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
  • Li Q; Ellehoj Redmond Consulting, Edmonton, Alberta T6G 0Y4, Canada.
  • Qiu Y; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
  • Maal-Bared R; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
  • Sikora C; EPCOR Water Canada, Edmonton, Alberta T5H 0E8, Canada.
  • Tipples G; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
  • Diggle M; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
  • Hinshaw D; Alberta Precision Laboratories, Edmonton, Alberta T6G 2J2, Canada.
  • Ashbolt NJ; Alberta Precision Laboratories, Edmonton, Alberta T6G 2J2, Canada.
  • Talbot J; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
  • Hrudey SE; Southern Cross University, Lismore, New South Wales 2480, Australia.
  • Lee BE; Department of Laboratory Medicine and Pathology, School of Public Health, Department of Medicine, and Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2E2, Canada.
ACS ES T Water ; 2(11): 2243-2254, 2022 Nov 11.
Article in English | MEDLINE | ID: covidwho-2115772
ABSTRACT
The correlations between SARS-CoV-2 RNA levels in wastewater from 12 wastewater treatment plants and new COVID-19 cases in the corresponding sewersheds of 10 communities were studied over 17 months. The analysis from the longest continuous surveillance reported to date revealed that SARS-CoV-2 RNA levels correlated well with temporal changes of COVID-19 cases in each community. The strongest correlation was found during the third wave (r = 0.97) based on the population-weighted SARS-CoV-2 RNA levels in wastewater. Different correlations were observed (r from 0.51 to 0.86) in various sizes of communities. The population in the sewershed had no observed effects on the strength of the correlation. Fluctuation of SARS-CoV-2 RNA levels in wastewater mirrored increases and decreases of COVID-19 cases in the corresponding community. Since the viral shedding to sewers from all infected individuals is included, wastewater-based surveillance provides an unbiased and no-discriminate estimation of the prevalence of COVID-19 compared with clinical testing that was subject to testing-seeking behaviors and policy changes. Wastewater-based surveillance on SARS-CoV-2 represents a temporal trend of COVID-19 disease burden and is an effective and supplementary monitoring when the number of COVID-19 cases reaches detectable thresholds of SARS-CoV-2 RNA in wastewater of treatment facilities serving various sizes of populations.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: ACS ES T Water Year: 2022 Document Type: Article Affiliation country: Acsestwater.2c00143

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Journal: ACS ES T Water Year: 2022 Document Type: Article Affiliation country: Acsestwater.2c00143