Autoimmune encephalitis after BBIBP-CorV (Sinopharm) COVID-19 vaccination: a case report.
BMC Neurol
; 22(1): 427, 2022 Nov 14.
Article
in English
| MEDLINE | ID: covidwho-2115832
ABSTRACT
BACKGROUND:
Vaccination is an important public health strategy; however, many neurological adverse effects are associated with COVID-19 vaccination, being encephalitis a rare manifestation. CASE PRESENTATION We present the case of a 33-year-old woman who received the first dose of the BBIBP-CorV vaccine against COVID-19 on April 4 and the second dose on April 28, 2021. Three days after receiving the second dose, she experienced a subacute episode of headache, fever, insomnia, and transient episodes of environment disconnection. We obtained negative results for infectious, systemic, and oncological causes. Brain magnetic resonance imaging showed lesions in the bilateral caudate nucleus and nonspecific demyelinating lesions at the supratentorial and infratentorial compartments. The results of the neuronal autoantibodies panel were negative. She had an adequate response to immunoglobulin and methylprednisolone; however, she experienced an early clinical relapse and received a new cycle of immunosuppressive treatment followed by a satisfactory clinical evolution.CONCLUSIONS:
We report the first case of severe encephalitis associated with BBIBP-CorV (Sinopharm) vaccination in Latin America. The patient had atypical imaging patterns, with early clinical relapse and a favorable response to corticosteroid therapy.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Encephalitis
/
COVID-19 Vaccines
/
COVID-19
Type of study:
Case report
/
Prognostic study
Topics:
Vaccines
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
BMC Neurol
Journal subject:
Neurology
Year:
2022
Document Type:
Article
Affiliation country:
S12883-022-02949-y
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