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Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection.
Balzanelli, Mario Giosuè; Distratis, Pietro; Lazzaro, Rita; Pham, Van Hung; Tran, Toai Cong; Dipalma, Gianna; Bianco, Angelica; Serlenga, Emilio Maria; Aityan, Sergey Khachatur; Pierangeli, Valentina; Nguyen, Kieu Cao Diem; Inchingolo, Francesco; Tomassone, Diego; Isacco, Ciro Gargiulo.
  • Balzanelli MG; SET-118, Department of Pre-Hospital and Emergency-San Giuseppe Moscati Hospital, 74100 Taranto, Italy.
  • Distratis P; SET-118, Department of Pre-Hospital and Emergency-San Giuseppe Moscati Hospital, 74100 Taranto, Italy.
  • Lazzaro R; SET-118, Department of Pre-Hospital and Emergency-San Giuseppe Moscati Hospital, 74100 Taranto, Italy.
  • Pham VH; Department of Microbiology and Virology, Phan Chau Trinh University of Medicine, Danang City 50000, Vietnam.
  • Tran TC; Department of Histology, Embryology and Genetics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 70000, Vietnam.
  • Dipalma G; Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.
  • Bianco A; Experimental Zooprophylactic Institute of Puglia and Basilicata, 71121 Foggia, Italy.
  • Serlenga EM; Hematology Department, Blood Transfusion Unit, SS Annunnziata Hospital, 74100 Taranto, Italy.
  • Aityan SK; Multidisciplinary Research Center, Lincoln University, Oakland, CA 94612, USA.
  • Pierangeli V; NEFLT NHS Foundation Trust, Rainham RM13 8EU, UK.
  • Nguyen KCD; Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.
  • Inchingolo F; Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.
  • Tomassone D; Foundation of Physics Research Center, 87053 Celico, Italy.
  • Isacco CG; Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.
Diagnostics (Basel) ; 12(11)2022 Nov 16.
Article in English | MEDLINE | ID: covidwho-2115958
ABSTRACT
Many factors may influence the risk of being infected by SARS-CoV-2, the coronavirus responsible for coronavirus disease 2019 (COVID-19). Exposure to the virus cannot explain the variety of an individual's responses to the virus and the high differences of effect that the virus may cause to some. While a person's preexisting condition and their immune defenses have been confirmed to play a major role in the disease progression, there is still much to learn about hosts' genetic makeup towards COVID-19 susceptibility and risk. The host genetic makeup may have direct influence on the grade of predisposition and outcomes of COVID-19. In this study, we aimed to investigate the presence of relevant genetic single nucleotide polymorphisms (SNPs), the peripheral blood level of IL6, vitamin D and arterial blood gas (ABG) markers (pH, oxygen-SpO2 and carbon dioxide-SpCO2) on two groups, COVID-19 (n = 41, study), and the healthy (n = 43, control). We analyzed cytokine and interleukin genes in charge of both pro-inflammatory and immune-modulating responses and those genes that are considered involved in the COVID-19 progression and complications. Thus, we selected major genes, such as IL1ß, IL1RN (IL-1 ß and α receptor) IL6, IL6R (IL-6 receptor), IL10, IFNγ (interferon gamma), TNFα (tumor necrosis factor alpha), ACE2 (angiotensin converting enzyme), SERPINA3 (Alpha-1-Antiproteinase, Antitrypsin member of Serpin 3 family), VDR (vitamin D receptor Tak1, Bsm1 and Fok1), and CRP (c-reactive protein). Though more research is needed, these findings may give a better representation of virus pleiotropic activity and its relation to the immune system.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12112824

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12112824