MSClustering: A Cytoscape Tool for Multi-Level Clustering of Biological Networks.
Int J Mol Sci
; 23(22)2022 Nov 17.
Article
in English
| MEDLINE | ID: covidwho-2295420
ABSTRACT
MSClustering is an efficient software package for visualizing and analyzing complex networks in Cytoscape. Based on the distance matrix of a network that it takes as input, MSClustering automatically displays the minimum span clustering (MSC) of the network at various characteristic levels. To produce a view of the overall network structure, the app then organizes the multi-level results into an MSC tree. Here, we demonstrate the package's phylogenetic applications in studying the evolutionary relationships of complex systems, including 63 beta coronaviruses and 197 GPCRs. The validity of MSClustering for large systems has been verified by its clustering of 3481 enzymes. Through an experimental comparison, we show that MSClustering outperforms five different state-of-the-art methods in the efficiency and reliability of their clustering.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Software
/
Computational Biology
Type of study:
Randomized controlled trials
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijms232214240
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