Your browser doesn't support javascript.
Circulating Serum Cystatin C as an Independent Risk Biomarker for Vascular Endothelial Dysfunction in Patients with COVID-19-Associated Multisystem Inflammatory Syndrome in Children (MIS-C): A Prospective Observational Study.
Kreslová, Marcela; Jehlicka, Petr; Sýkorová, Aneta; Rajdl, Daniel; Klásková, Eva; Prokop, Pavel; Kaprálová, Sabina; Pavlícek, Jan; Kaslová, Romana; Palátová, Alzbeta; Mohylová, Veronika; Sýkora, Josef.
  • Kreslová M; Department of Pediatrics, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic.
  • Jehlicka P; Department of Pediatrics, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic.
  • Sýkorová A; Department of Pediatrics, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic.
  • Rajdl D; Department of Clinical Biochemistry and Hematology, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic.
  • Klásková E; Department of Pediatrics, Faculty Hospital, Faculty of Medicine and Dentistry, Palacky University in Olomouc, I. P. Pavlova 185/6, 77520 Olomouc, Czech Republic.
  • Prokop P; Department of Clinical Biochemistry and Hematology, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic.
  • Kaprálová S; Department of Pediatrics, Faculty Hospital, Faculty of Medicine and Dentistry, Palacky University in Olomouc, I. P. Pavlova 185/6, 77520 Olomouc, Czech Republic.
  • Pavlícek J; Department of Pediatrics, Faculty Hospital, Faculty of Medicine, Ostrava University, 17. Listopadu 1790, 70852 Ostrava, Czech Republic.
  • Kaslová R; Department of Pediatrics, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic.
  • Palátová A; Department of Pediatrics, Faculty Hospital, Faculty of Medicine and Dentistry, Palacky University in Olomouc, I. P. Pavlova 185/6, 77520 Olomouc, Czech Republic.
  • Mohylová V; Department of Pediatrics, Faculty Hospital, Faculty of Medicine, Ostrava University, 17. Listopadu 1790, 70852 Ostrava, Czech Republic.
  • Sýkora J; Department of Pediatrics, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 30460 Pilsen, Czech Republic.
Biomedicines ; 10(11)2022 Nov 17.
Article in English | MEDLINE | ID: covidwho-2116110
ABSTRACT

INTRODUCTION:

Multisystem inflammatory syndrome in children (MIS-C) is a new clinical entity that has emerged in the context of the COVID-19 pandemic. Despite the less severe course of the disease, varying degrees of cardiovascular events may occur in MIS-C; however, data on vascular changes occurring in MIS-C are still lacking. Endothelial dysfunction (ED) is thought to be one of the key risk factors contributing to MIS-C.

BACKGROUND:

We conducted a prospective observational study. We investigated possible manifestations of cardiac and endothelial involvement in MIS-C after the treatment of the acute stage and potential predictive biomarkers in patients with MIS-C.

METHODS:

Twenty-seven consecutive pediatric subjects (≥9 years), at least three months post-treated MIS-C of varying severity, in a stable condition, and twenty-three age- and sex-matched healthy individuals (HI), were enrolled. A combined non-invasive diagnostic approach was used to assess endothelial function as well as markers of organ damage using cardiac examination and measurement of the reactive hyperemia index (RHI), by recording the post- to pre-occlusion pulsatile volume changes and biomarkers related to ED and cardiac disease.

RESULTS:

MIS-C patients exhibited a significantly lower RHI (indicative of more severe ED) than those in HI (1.32 vs. 1.80; p = 0.001). The cutoff of RHI ≤ 1.4 was independently associated with a higher cardiovascular risk. Age and biomarkers significantly correlated with RHI, while serum cystatin C (Cys C) levels were independently associated with a diminished RHI, suggesting Cys C as a surrogate marker of ED in MIS-C.

CONCLUSIONS:

Patients after MIS-C display evidence of ED, as shown by a diminished RHI and altered endothelial biomarkers. Cys C was identified as an independent indicator for the development of cardiovascular disease. The combination of these factors has the potential to better predict the cardiovascular consequences of MIS-C. Our study suggests that ED may be implicated in the pathophysiology of this disease.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Biomedicines10112956

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Biomedicines10112956