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Childhood Pemphigus Vulgaris during COVID-19 Outbreak Successfully Treated with Prednisone and Azathioprine: A Case Report and Literature Review.
Vezzoli, Pamela; Parietti, Michele; Carugno, Andrea; Di Mercurio, Marco; Benaglia, Chiara; Zussino, Martina; Cavalli, Riccardo; Sena, Paolo; Berti, Emilio.
  • Vezzoli P; Dermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
  • Parietti M; Dermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
  • Carugno A; Dermatology Unit, Department of Medical Sciences, University of Turin, 10124 Turin, Italy.
  • Di Mercurio M; Dermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
  • Benaglia C; Ph.D. Program in Molecular and Translational Medicine (DIMET), University of Milan-Bicocca, 20126 Milan, Italy.
  • Zussino M; Dermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
  • Cavalli R; Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy.
  • Sena P; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.
  • Berti E; Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy.
J Clin Med ; 11(22)2022 Nov 21.
Article in English | MEDLINE | ID: covidwho-2116243
ABSTRACT

INTRODUCTION:

pemphigus vulgaris is a rare autoimmune blistering disease that involves the skin and mucous membranes and rarely occurs in pediatric age.

METHODS:

we present a case of childhood pemphigus in a 9-year-old patient from Burkina Faso, which initially manifested with erosive lesions symmetrically distributed in the oral cavity. After a few months, we also observed hyperchromic lesions of the back. Histopathological examination of skin samples showed intraepidermal acantholysis, while direct immunofluorescence showed deposits of complement (C3) and immunoglobulins G (IgG) in the epidermidis; an ELISA test highlighted the presence of circulating autoantibodies against desmoglein 3.

RESULTS:

the follow-up of this patient was made difficult by the advent of the COVID-19 outbreak. However, after about one year of combined therapy with systemic steroids and azathioprine the patient reached clinical remission.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study / Reviews Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11226858

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study / Reviews Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11226858