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The oldest unvaccinated Covid-19 survivors in South America.
de Castro, Mateus V; Silva, Monize V R; Naslavsky, Michel S; Scliar, Marilia O; Nunes, Kelly; Passos-Bueno, Maria Rita; Castelli, Erick C; Magawa, Jhosiene Y; Adami, Flávia L; Moretti, Ana I S; de Oliveira, Vivian L; Boscardin, Silvia B; Cunha-Neto, Edecio; Kalil, Jorge; Jouanguy, Emmanuelle; Bastard, Paul; Casanova, Jean-Laurent; Quiñones-Vega, Mauricio; Sosa-Acosta, Patricia; Guedes, Jéssica de S; de Almeida, Natália P; Nogueira, Fábio C S; Domont, Gilberto B; Santos, Keity S; Zatz, Mayana.
  • de Castro MV; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Silva MVR; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Naslavsky MS; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Scliar MO; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Nunes K; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Passos-Bueno MR; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Castelli EC; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Magawa JY; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Adami FL; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Moretti AIS; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil.
  • de Oliveira VL; Department of Pathology, School of Medicine, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil.
  • Boscardin SB; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil.
  • Cunha-Neto E; Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil.
  • Kalil J; Departamento de Clínica Médica, Disciplina de Imunologia Clínica e Alergia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Jouanguy E; Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Bastard P; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil.
  • Casanova JL; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil.
  • Quiñones-Vega M; Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Sosa-Acosta P; Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil.
  • Guedes JS; Departamento de Clínica Médica, Disciplina de Imunologia Clínica e Alergia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • de Almeida NP; Laboratório de Imunologia, Instituto do Coração (InCor), LIM19, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil.
  • Nogueira FCS; Instituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil.
  • Domont GB; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
  • Santos KS; Imagine Institute, University of Paris, Paris, France.
  • Zatz M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Immun Ageing ; 19(1): 57, 2022 Nov 16.
Article in English | MEDLINE | ID: covidwho-2116656
ABSTRACT

BACKGROUND:

Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated.

RESULTS:

Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN.

CONCLUSION:

These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Language: English Journal: Immun Ageing Year: 2022 Document Type: Article Affiliation country: S12979-022-00310-y

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Language: English Journal: Immun Ageing Year: 2022 Document Type: Article Affiliation country: S12979-022-00310-y