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Pulmonary function and Quality of Life in a prospective cohort of (non-) hospitalized COVID-19 pneumonia survivors up to six months.
de Roos, Marlise P; Siegerink, Sebastiaan; Dijkstra, Nynke G; Broekman, Birit Fp; Brinkman, Kees; Jonkman, Nini H; Bresser, Paul.
  • de Roos MP; Department of Respiratory Medicine, 10215OLVG, Amsterdam, The Netherlands.
  • Siegerink S; Department of Medical Psychiatry, 10215Amsterdam UMC and OLVG, Amsterdam, The Netherlands.
  • Dijkstra NG; Department of Respiratory Medicine, 10215OLVG, Amsterdam, The Netherlands.
  • Broekman BF; Department of Medical Psychiatry, 10215Amsterdam UMC and OLVG, Amsterdam, The Netherlands.
  • Brinkman K; Department of Internal Medicine and Infectious diseases, 10215OLVG, Amsterdam, The Netherlands.
  • Jonkman NH; Department of Research and Epidemiology, 10215OLVG, Amsterdam, The Netherlands.
  • Bresser P; Department of Respiratory Medicine, 10215OLVG, Amsterdam, The Netherlands.
Chron Respir Dis ; 19: 14799731221114271, 2022.
Article in English | MEDLINE | ID: covidwho-2116667
ABSTRACT

OBJECTIVES:

A decrease of both diffusion capacity (DLCO) and Quality of Life (QoL) was reported after discharge in hospitalized COVID-19 pneumonia survivors. We studied three and 6 month outcomes in hospitalized and non-hospitalized patients.

METHODS:

COVID-19 pneumonia survivors (n = 317) were categorized into non-hospitalized "moderate" cases (n = 59), hospitalized "severe" cases (n = 180) and ICU-admitted "critical" cases (n = 39). We studied DLCO and QoL (Short Form SF-36 health survey) 3 and 6 months after discharge. Data were analyzed using (repeated measures) ANOVA, Kruskal-Wallis or Chi-square test (p < .05).

RESULTS:

At 3 months DLCO was decreased in 44% of moderate-, 56% of severe- and 82% of critical cases (p < .003). Mean DLCO in critical cases (64±14%) was lower compared to severe (76 ± 17%) and moderate (81±15%) cases (p < .001). A total of 159/278 patients had a decreased DLCO (<80%), of whom the DLCO improved after 6 months in 45% (71/159). However the DLCO did not normalize in the majority (89%) of the cases (63 ± 10% vs 68±10%; p < .001). At 3 months, compared to critical cases, moderate cases scored lower on SF-36 domain "general health" (p < .05); both moderate and severe cases scored lower on the domain of "health change" (p < .05). At 6 months, there were no differences in SF-36 between the subgroups. Compared to 3 months, in all groups "physical functioning" improved; in contrast all groups scored significantly lower on "non-physical" SF-36 domains.

CONCLUSION:

Three months after COVID-19 pneumonia, DLCO was still decreased in the more severely affected patients, with an incomplete recovery after 6 months. At 3 months QoL was impaired. At 6 months, while "physical functioning" improved, a decrease in "non-physical" QoL was observed but did not differ between the moderate and severely affected patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Chron Respir Dis Year: 2022 Document Type: Article Affiliation country: 14799731221114271

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Chron Respir Dis Year: 2022 Document Type: Article Affiliation country: 14799731221114271