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Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction.
Dentone, Chiara; Fenoglio, Daniela; Parodi, Alessia; Altosole, Tiziana; Di Biagio, Antonio; Bozzano, Federica; Nasi, Giorgia; Vena, Antonio; Fabbi, Marina; Ferrera, Francesca; Bruzzone, Bianca; Giacomini, Mauro; Giacobbe, Daniele Roberto; Pelosi, Paolo; De Maria, Andrea; Bassetti, Matteo; De Palma, Raffaele; Filaci, Gilberto.
  • Dentone C; Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy. chiaradentone@libero.it.
  • Fenoglio D; Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Parodi A; Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
  • Altosole T; Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Di Biagio A; Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
  • Bozzano F; Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
  • Nasi G; Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.
  • Vena A; Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
  • Fabbi M; Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Ferrera F; Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.
  • Bruzzone B; Biotherapies Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Giacomini M; Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, 16132, Genoa, Italy.
  • Giacobbe DR; Hygiene Unit, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
  • Pelosi P; Department of Informatics Bioengineering, Robotics, and Systems Engineering (DIBRIS), University of Genoa, 16145, Genoa, Italy.
  • De Maria A; Division of Infectious Diseases, IRCCS Ospedale Policlinico San Martino - IRCCS, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy.
  • Bassetti M; Department of Health Sciences, University of Genoa, 16132, Genoa, Italy.
  • De Palma R; Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132, Genoa, Italy.
  • Filaci G; Anesthesia and Intensive Care Unit, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Clin Exp Med ; 2022 Nov 13.
Article in English | MEDLINE | ID: covidwho-2116678
ABSTRACT
Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C-C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: S10238-022-00927-9

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: S10238-022-00927-9