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[ORGANIZATION OF GENOMIC SURVEILLANCE FOR SARS-CoV-2 WITHIN THE MOSCOW CITY HEALTH DEPARTMENT].
Latypova, M F; Tsibin, A N; Komarov, A G; Romanova, V A; Speshilov, G I; Tarnovetsky, I Y.
  • Latypova MF; Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department.
  • Tsibin AN; Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department.
  • Komarov AG; Diagnostic Center (Laboratory Testing Center) of Moscow Heаlthcare Department.
  • Romanova VA; Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department.
  • Speshilov GI; Diagnostic Center (Laboratory Testing Center) of Moscow Heаlthcare Department.
  • Tarnovetsky IY; Diagnostic Center (Laboratory Testing Center) of Moscow Heаlthcare Department.
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med ; 30(s1): 1061-1066, 2022 Dec 15.
Article in Russian | MEDLINE | ID: covidwho-2117183
ABSTRACT
An important goal of COVID-19 surveillance is to detect outbreaks using modern molecular epidemiology techniques based on methods to decode the full genome of the virus, since rapidly evolving RNA viruses, which include SARS-CoV-2, are constantly accumulating changes in their genomes. In addition to using these changes to identify the different virus lines spreading in the population, the availability of sequence information is very important. It will allow the identification of altered variants that may be more transmissible, cause more severe forms of disease, or be undetectable by existing diagnostic test systems. The global scientific community is particularly interested in changes in the spike protein (S-protein, Spike) because they are responsible for binding and penetration into the host cell, lead to false-negative results in diagnostic tests, and affect transmission rates, health outcomes, therapeutic interventions, and vaccine efficacy.Genomic surveillance uses next-generation sequencing (NGS) applications and makes data on the full genome of the virus available. These methods offer new means to detect variants that differ phenotypically or antigenically. This approach promotes earlier prediction as well as effective strategies to mitigate and contain outbreaks of SARS-CoV-2 and other new viruses long before they spread worldwide.Today, molecular typing of strains is playing an increasingly important role in this process, as it makes it possible to identify samples that share a common molecular «fingerprint¼.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Humans Country/Region as subject: Europa Language: Russian Journal: Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med Journal subject: Public Health Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Humans Country/Region as subject: Europa Language: Russian Journal: Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med Journal subject: Public Health Year: 2022 Document Type: Article