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MORPHOLOGICAL AND FUNCTIONAL FEATURES OF THE MUCOUS MEMBRANE OF SMALL AND LARGE INTESTINE IN PATIENTS WITH COVID-19 AND IN POST-COVID-19 PERIOD.
Myroshnychenko, Mykhailo S; Torianyk, Inna I; Arseniev, Oleksandr V; Franchuk, Valentyn V; Zaytseva, Olga V; Moiseienko, Tetiana M; Bondarenko, Maryna A; Popova, Natalia G; Melnyk, Anatoliy L; Mozhaiev, Ivan V; Osolodchenko, Tetiana P; Molodan, Dmytro V.
  • Myroshnychenko MS; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Torianyk II; STATE INSTITUTION «INSTITUTE OF MICROBIOLOGY AND IMMUNOLOGY NAMED BY I.I. МЕCHNIKOV NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE¼, KHARKIV, UKRAINE.
  • Arseniev OV; KHARKIV INTERNATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Franchuk VV; I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.
  • Zaytseva OV; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Moiseienko TM; STATE INSTITUTION «INSTITUTE OF MICROBIOLOGY AND IMMUNOLOGY NAMED BY I.I. МЕCHNIKOV NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE¼, KHARKIV, UKRAINE.
  • Bondarenko MA; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Popova NG; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
  • Melnyk AL; ZAPORIZHZHIA STATE MEDICAL UNIVERSITY, ZAPORIZHZHIA, UKRAINE.
  • Mozhaiev IV; STATE INSTITUTION «INSTITUTE OF MICROBIOLOGY AND IMMUNOLOGY NAMED BY I.I. МЕCHNIKOV NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE¼, KHARKIV, UKRAINE.
  • Osolodchenko TP; STATE INSTITUTION «INSTITUTE OF MICROBIOLOGY AND IMMUNOLOGY NAMED BY I.I. МЕCHNIKOV NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE¼, KHARKIV, UKRAINE.
  • Molodan DV; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Wiad Lek ; 75(9 pt 2): 2198-2203, 2022.
Article in English | MEDLINE | ID: covidwho-2117417
ABSTRACT

OBJECTIVE:

The

aim:

To reveal the morphological and functional features of the mucous membrane of small and large intestine in patients with COVID-19 and in post-COVID-19 period. PATIENTS AND

METHODS:

Materials and

methods:

In the present study, the authors used biopsy and autopsy material represented by the fragments of the mucous membrane of small and large intestine. All studied material was divided into 10 groups. Group 1 (comparison group) included autopsy material from the deceased who did not have COVID-19 during their lifetime. Groups 2-4 included autopsy material from the deceased who had COVID-19 of varying severity during their lifetime. Groups 5-7 included biopsy material from patients who had recovered from COVID-19 of varying severity, while the duration of the post-COVID period ranged from 1 to 50 days. Groups 8-10 included biopsy material from patients who had in anamnesis COVID-19 of varying severity (the duration of the post-COVID period lasted from 51 to 100 days). Histological, immunohistochemical, morphometric and statistical research methods were used.

RESULTS:

Results:

The comparative analysis showed a more expressed deficiency of ACE2 in the mucous membrane of small and large intestine in patients with moderate and severe COVID-19 compared with patients in post-COVID-19 period of different duration. In patients who had moderate and severe COVID-19 in anamnesis, ACE2 deficiency decreases with increasing duration of post-COVID-19 period. In patients recovered from mild COVID-19, the ACE2 content increases with the duration of post-COVID-19 period from 1 to 50 days and corresponds to the norm with the duration of this period from 51 to 100 days.

CONCLUSION:

Conclusions:

The comprehensive morphological study conducted by the authors made it possible, firstly, to clarify the morphological and functional features of the mucous membrane of small and large intestine in patients with COVID-19 of various degrees of severity; secondly, to obtain new data about the morpho-functional state of the mucous membrane of small and large intestine in patients, taking into account different duration of the post-COVID-19 period and the severity of the infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Wiad Lek Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: WLek202209203

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Wiad Lek Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: WLek202209203