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Lipidomic signatures align with inflammatory patterns and outcomes in critical illness.
Wu, Junru; Cyr, Anthony; Gruen, Danielle S; Lovelace, Tyler C; Benos, Panayiotis V; Das, Jishnu; Kar, Upendra K; Chen, Tianmeng; Guyette, Francis X; Yazer, Mark H; Daley, Brian J; Miller, Richard S; Harbrecht, Brian G; Claridge, Jeffrey A; Phelan, Herb A; Zuckerbraun, Brian S; Neal, Matthew D; Johansson, Pär I; Stensballe, Jakob; Namas, Rami A; Vodovotz, Yoram; Sperry, Jason L; Billiar, Timothy R.
  • Wu J; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Cyr A; Pittsburgh Trauma Research Center, Division of Trauma and Acute Care Surgery, Pittsburgh, PA, USA.
  • Gruen DS; Department of Cardiology, The 3rd Xiangya Hospital, Central South University, Changsha, China.
  • Lovelace TC; Eight-year program of medicine, Xiangya School of Medicine, Central South University, Changsha, China.
  • Benos PV; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Das J; Pittsburgh Trauma Research Center, Division of Trauma and Acute Care Surgery, Pittsburgh, PA, USA.
  • Kar UK; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Chen T; Pittsburgh Trauma Research Center, Division of Trauma and Acute Care Surgery, Pittsburgh, PA, USA.
  • Guyette FX; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Yazer MH; Joint CMU-Pitt PhD Program in Computational Biology, Pittsburgh, PA, USA.
  • Daley BJ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Miller RS; Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Harbrecht BG; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Claridge JA; Pittsburgh Trauma Research Center, Division of Trauma and Acute Care Surgery, Pittsburgh, PA, USA.
  • Phelan HA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Zuckerbraun BS; Cellular and Molecular Pathology Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Neal MD; Department of Emergency Medicine, Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Johansson PI; The Institute for Transfusion Medicine, Pittsburgh, PA, USA.
  • Stensballe J; Department of Surgery, University of Tennessee Health Science Center, Knoxville, TN, USA.
  • Namas RA; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Vodovotz Y; Department of Surgery, University of Louisville, Louisville, KY, USA.
  • Sperry JL; Metro Health Medical Center, Case Western Reserve University, Cleveland, OH, USA.
  • Billiar TR; Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.
Nat Commun ; 13(1): 6789, 2022 Nov 10.
Article in English | MEDLINE | ID: covidwho-2118042
ABSTRACT
Alterations in lipid metabolism have the potential to be markers as well as drivers of pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. The previously reported survival benefit of early thawed plasma administration was associated with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers in causal modelling. Phosphatidylethanolamines (PE) were elevated in patients with persistent critical illness and PE levels were prognostic for worse outcomes not only in trauma but also severe COVID-19 patients. Here we show selective rise in systemic PE as a common prognostic feature of critical illness.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34420-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34420-4