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A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae.
George, Peter M; Reed, Anna; Desai, Sujal R; Devaraj, Anand; Faiez, Tasnim Shahridan; Laverty, Sarah; Kanwal, Amama; Esneau, Camille; Liu, Michael K C; Kamal, Faisal; Man, William D-C; Kaul, Sundeep; Singh, Suveer; Lamb, Georgia; Faizi, Fatima K; Schuliga, Michael; Read, Jane; Burgoyne, Thomas; Pinto, Andreia L; Micallef, Jake; Bauwens, Emilie; Candiracci, Julie; Bougoussa, Mhammed; Herzog, Marielle; Raman, Lavanya; Ahmetaj-Shala, Blerina; Turville, Stuart; Aggarwal, Anupriya; Farne, Hugo A; Dalla Pria, Alessia; Aswani, Andrew D; Patella, Francesca; Borek, Weronika E; Mitchell, Jane A; Bartlett, Nathan W; Dokal, Arran; Xu, Xiao-Ning; Kelleher, Peter; Shah, Anand; Singanayagam, Aran.
  • George PM; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Reed A; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Desai SR; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Devaraj A; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Faiez TS; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Laverty S; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Kanwal A; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Esneau C; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Liu MKC; Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London, London SW7 2DD, UK.
  • Kamal F; Section of Virology, Department of Infectious Disease, Imperial College London, London W2 1PG, UK.
  • Man WD; Faculty of Health, Medicine and Wellbeing, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Kaul S; Faculty of Health, Medicine and Wellbeing, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Singh S; Section of Virology, Department of Infectious Disease, Imperial College London, London W2 1PG, UK.
  • Lamb G; Royal Berkshire Hospital, Reading RG1 5AN, UK.
  • Faizi FK; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Schuliga M; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Read J; Faculty of Life Sciences and Medicine, King's College London, London WC2R 2LS, UK.
  • Burgoyne T; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Pinto AL; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Micallef J; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Bauwens E; Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College London, London SW7 2DD, UK.
  • Candiracci J; Faculty of Health, Medicine and Wellbeing, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Bougoussa M; Faculty of Health, Medicine and Wellbeing, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Herzog M; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Raman L; UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
  • Ahmetaj-Shala B; Royal Brompton and Harefield Clinical Group, Guy's and St. Thomas' NHS Foundation Trust, London SW3 6NR, UK.
  • Turville S; Belgian Volition SRL, 22 rue Phocas Lejeune, Parc Scientifique Créalys, Isnes 5032, Belgium.
  • Aggarwal A; Belgian Volition SRL, 22 rue Phocas Lejeune, Parc Scientifique Créalys, Isnes 5032, Belgium.
  • Farne HA; Belgian Volition SRL, 22 rue Phocas Lejeune, Parc Scientifique Créalys, Isnes 5032, Belgium.
  • Dalla Pria A; Belgian Volition SRL, 22 rue Phocas Lejeune, Parc Scientifique Créalys, Isnes 5032, Belgium.
  • Aswani AD; Belgian Volition SRL, 22 rue Phocas Lejeune, Parc Scientifique Créalys, Isnes 5032, Belgium.
  • Patella F; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Borek WE; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Mitchell JA; The Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
  • Bartlett NW; The Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
  • Dokal A; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Xu XN; The Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
  • Kelleher P; Chest and Allergy Department, St Mary's Hospital, Imperial College NHS Trust, London W2 1NY, UK.
  • Shah A; Section of Virology, Department of Infectious Disease, Imperial College London, London W2 1PG, UK.
  • Singanayagam A; Department of HIV and Genitourinary Medicine, Chelsea and Westminster NHS Foundation Trust, London SW10 9NH, UK.
Sci Transl Med ; 14(671): eabo5795, 2022 Nov 16.
Article in English | MEDLINE | ID: covidwho-2119264
ABSTRACT
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps / COVID-19 Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Sci Transl Med Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Scitranslmed.abo5795

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps / COVID-19 Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Sci Transl Med Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Scitranslmed.abo5795