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High-temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines.
Rinchai, Darawan; Deola, Sara; Zoppoli, Gabriele; Kabeer, Basirudeen Syed Ahamed; Taleb, Sara; Pavlovski, Igor; Maacha, Selma; Gentilcore, Giusy; Toufiq, Mohammed; Mathew, Lisa; Liu, Li; Vempalli, Fazulur Rehaman; Mubarak, Ghada; Lorenz, Stephan; Sivieri, Irene; Cirmena, Gabriella; Dentone, Chiara; Cuccarolo, Paola; Giacobbe, Daniele Roberto; Baldi, Federico; Garbarino, Alberto; Cigolini, Benedetta; Cremonesi, Paolo; Bedognetti, Michele; Ballestrero, Alberto; Bassetti, Matteo; Hejblum, Boris P; Augustine, Tracy; Van Panhuys, Nicholas; Thiebaut, Rodolphe; Branco, Ricardo; Chew, Tracey; Shojaei, Maryam; Short, Kirsty; Feng, Carl G; Zughaier, Susu M; De Maria, Andrea; Tang, Benjamin; Ait Hssain, Ali; Bedognetti, Davide; Grivel, Jean-Charles; Chaussabel, Damien.
  • Rinchai D; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Deola S; Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA.
  • Zoppoli G; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Kabeer BSA; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Taleb S; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
  • Pavlovski I; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Maacha S; Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
  • Gentilcore G; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Toufiq M; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Mathew L; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Liu L; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Vempalli FR; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Mubarak G; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Lorenz S; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Sivieri I; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Cirmena G; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Dentone C; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
  • Cuccarolo P; Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Giacobbe DR; Department of Experimental and Clinical Medicine, School of Internal Medicine, University of Florence, Florence, Italy.
  • Baldi F; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Garbarino A; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Cigolini B; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
  • Cremonesi P; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Bedognetti M; Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Ballestrero A; Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Bassetti M; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
  • Hejblum BP; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
  • Augustine T; Emergency Department, E.O. Ospedali Galliera, Genova, Italy.
  • Van Panhuys N; Azienda Sanitaria Locale 3 Genovese, Genova, Liguria, Italy.
  • Thiebaut R; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Branco R; Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Chew T; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Shojaei M; Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Short K; Univ. Bordeaux, Department of Public Health, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, F-33000 Bordeaux, France.
  • Feng CG; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Zughaier SM; Univ. Bordeaux, Department of Public Health, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, F-33000 Bordeaux, France.
  • De Maria A; Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.
  • Tang B; Sydney Informatic Hub, The University of Sydney, Sydney, New South Wales, Australia.
  • Ait Hssain A; Nepean Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Bedognetti D; Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
  • Grivel JC; Department of Medicine, Sydney Medical School, Nepean Hospital, The University of Sydney, Sydney, New South Wales, Australia.
  • Chaussabel D; The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, Brisbane, Queensland, Australia.
Sci Adv ; 8(45): eabp9961, 2022 11 11.
Article in English | MEDLINE | ID: covidwho-2119401
ABSTRACT
Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high-temporal resolution blood transcriptome profiling. The first vaccine dose elicited modest interferon and adaptive immune responses, which peaked on days 2 and 5, respectively. The second vaccine dose, in contrast, elicited sharp day 1 interferon, inflammation, and erythroid cell responses, followed by a day 5 plasmablast response. Both post-first and post-second dose interferon signatures were associated with the subsequent development of antibody responses. Yet, we observed distinct interferon response patterns after each of the doses that may reflect quantitative or qualitative differences in interferon induction. Distinct interferon response phenotypes were also observed in patients with COVID-19 and were associated with severity and differences in duration of intensive care. Together, this study also highlights the benefits of adopting high-frequency sampling protocols in profiling vaccine-elicited immune responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Prognostic study / Qualitative research Topics: Vaccines Limits: Humans Language: English Journal: Sci Adv Year: 2022 Document Type: Article Affiliation country: Sciadv.abp9961

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Prognostic study / Qualitative research Topics: Vaccines Limits: Humans Language: English Journal: Sci Adv Year: 2022 Document Type: Article Affiliation country: Sciadv.abp9961