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Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children.
Sinkovits, György; Schnur, János; Hurler, Lisa; Kiszel, Petra; Prohászka, Zita Z; Sík, Pál; Kajdácsi, Erika; Cervenak, László; Maráczi, Veronika; Dávid, Máté; Zsigmond, Borbála; Rimanóczy, Éva; Bereczki, Csaba; Willems, Loek; Toonen, Erik J M; Prohászka, Zoltán.
  • Sinkovits G; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1085, Hungary. sinkovits.gyorgy@med.semmelweis-univ.hu.
  • Schnur J; Heim Pál National Pediatric Institute, Budapest, 1089, Hungary.
  • Hurler L; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1085, Hungary.
  • Kiszel P; Research Group for Immunology and Hematology, Semmelweis University-Eötvös Loránd Research Network (Office for Supported Research Groups), Budapest, 1085, Hungary.
  • Prohászka ZZ; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1085, Hungary.
  • Sík P; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1085, Hungary.
  • Kajdácsi E; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1085, Hungary.
  • Cervenak L; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1085, Hungary.
  • Maráczi V; Heim Pál National Pediatric Institute, Budapest, 1089, Hungary.
  • Dávid M; Heim Pál National Pediatric Institute, Budapest, 1089, Hungary.
  • Zsigmond B; Heim Pál National Pediatric Institute, Budapest, 1089, Hungary.
  • Rimanóczy É; Heim Pál National Pediatric Institute, Budapest, 1089, Hungary.
  • Bereczki C; Department of Pediatrics, University of Szeged, Szeged, 6720, Hungary.
  • Willems L; R&D Department, Hycult Biotech, 5405, PB, Uden, The Netherlands.
  • Toonen EJM; R&D Department, Hycult Biotech, 5405, PB, Uden, The Netherlands.
  • Prohászka Z; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, 1085, Hungary.
Sci Rep ; 12(1): 19759, 2022 Nov 17.
Article in English | MEDLINE | ID: covidwho-2119432
ABSTRACT
Multisystem inflammatory syndrome in children (MIS-C) is a rare, life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. MIS-C develops with high fever, marked inflammation and shock-like picture several weeks after exposure to, or mild infection with SARS-CoV-2. Deep immune profiling identified activated macrophages, neutrophils, B-plasmablasts and CD8 + T cells as key determinants of pathogenesis together with multiple inflammatory markers. The disease rapidly responds to intravenous immunoglobulin (IVIG) treatment with clear changes of immune features. Here we present the results of a comprehensive analysis of the complement system in the context of MIS-C activity and describe characteristic changes during IVIG treatment. We show that activation markers of the classical, alternative and terminal pathways are highly elevated, that the activation is largely independent of anti-SARS-CoV-2 humoral immune response, but is strongly associated with markers of macrophage activation. Decrease of complement activation is closely associated with rapid improvement of MIS-C after IVIG treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Child / Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-23806-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Child / Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-23806-5