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Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant.
Sitaras, Ioannis; Jacobsen, Henning; Higdon, Melissa M; Dowling, William E; Bar-Zeev, Naor; Deloria Knoll, Maria.
  • Sitaras I; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. isitara1@jh.edu.
  • Jacobsen H; Department of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Higdon MM; International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Dowling WE; Coalition for Epidemic Preparedness Innovations, Washington DC, USA.
  • Bar-Zeev N; International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Deloria Knoll M; International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
NPJ Vaccines ; 7(1): 147, 2022 Nov 15.
Article in English | MEDLINE | ID: covidwho-2119433
ABSTRACT
Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Language: English Journal: NPJ Vaccines Year: 2022 Document Type: Article Affiliation country: S41541-022-00565-y

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Language: English Journal: NPJ Vaccines Year: 2022 Document Type: Article Affiliation country: S41541-022-00565-y