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Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England.
Whitaker, Matthew; Elliott, Joshua; Bodinier, Barbara; Barclay, Wendy; Ward, Helen; Cooke, Graham; Donnelly, Christl A; Chadeau-Hyam, Marc; Elliott, Paul.
  • Whitaker M; School of Public Health, Imperial College London, London, UK.
  • Elliott J; MRC Centre for Environment and Health, Imperial College London, London, UK.
  • Bodinier B; Imperial College Healthcare NHS Trust, London, UK.
  • Barclay W; Department of Infectious Disease, Imperial College London, London, UK.
  • Ward H; School of Public Health, Imperial College London, London, UK.
  • Cooke G; MRC Centre for Environment and Health, Imperial College London, London, UK.
  • Donnelly CA; Department of Infectious Disease, Imperial College London, London, UK.
  • Chadeau-Hyam M; Imperial College Healthcare NHS Trust, London, UK.
  • Elliott P; MRC Centre for Global Infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
Nat Commun ; 13(1): 6856, 2022 Nov 11.
Article in English | MEDLINE | ID: covidwho-2119477
ABSTRACT
Infection with SARS-CoV-2 virus is associated with a wide range of symptoms. The REal-time Assessment of Community Transmission -1 (REACT-1) study monitored the spread and clinical manifestation of SARS-CoV-2 among random samples of the population in England from 1 May 2020 to 31 March 2022. We show changing symptom profiles associated with the different variants over that period, with lower reporting of loss of sense of smell or taste for Omicron compared to previous variants, and higher reporting of cold-like and influenza-like symptoms, controlling for vaccination status. Contrary to the perception that recent variants have become successively milder, Omicron BA.2 was associated with reporting more symptoms, with greater disruption to daily activities, than BA.1. With restrictions lifted and routine testing limited in many countries, monitoring the changing symptom profiles associated with SARS-CoV-2 infection and effects on daily activities will become increasingly important.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Adult / Humans Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34244-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Adult / Humans Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34244-2