Low thoracic skeletal muscle index is associated with negative outcomes in 244 patients with respiratory COVID-19.
Clin Nutr
; 42(2): 102-107, 2023 02.
Article
in English
| MEDLINE | ID: covidwho-2120089
ABSTRACT
BACKGROUND:
Sarcopenia is associated with negative outcomes in intensive care unit (ICU) patients and during chronic diseases. We aimed to evaluate if low skeletal muscle index (SMI) measured by computed tomography (CT) at the thoracic level is associated with poor outcomes in hospitalized patients with respiratory COVID-19.METHODS:
Patients admitted to the hospital between March 1st and June 9, 2020 with a confirmed diagnosis of respiratory COVID-19 in the Emergency Department were included in this retrospective cohort study. SMI was assessed from a transverse CT image at the T12 level. We analysed the association between thoracic SMI and mortality, ICU admissions, infections, length of stay and gravity scores.RESULTS:
We included 244 patients, whose median age was 62 (20-95) years, mean body mass index was 28,6 kg/m2, and 34% were obese patients. 102 patients (41,8%) had low thoracic SMI. On multivariable analysis, low thoracic SMI was associated with more infections (OR = 1,88 [1,06-2,98]) and increased length of stay (OR = 1,87 [1,14-3,49]) but not with mortality (OR = 1.37 [0.54-3.52]), whereas it was inversely associated with ICU admission (OR = 5,56 [1,96-16,67].CONCLUSION:
Low SMI measured by CT at the thoracic level T12 is associated with negative outcomes in patients with respiratory COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sarcopenia
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
/
Middle aged
Language:
English
Journal:
Clin Nutr
Year:
2023
Document Type:
Article
Affiliation country:
J.clnu.2022.11.011
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