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SARS-CoV-2 viral shedding in vaccinated and unvaccinated persons: A case series.
McCormick, David W; Hagan, Liesl M; Salvatore, Phillip P; Magleby, Reed; Lee, Christine; Sleweon, Sadia; Nicolae, Lavinia; Dixon, Tom; Banta, Robert; Ogle, Isaac; Young, Cristen; Dusseau, Charles; Ogden, Charles; Browne, Hannah; Michael Metz, John; Chen, Min-Hsin; Solano, Maria I; Rogers, Shannon; Burgin, Alex; Sheth, Mili; Bankamp, Bettina; Tamin, Azaibi; Harcourt, Jennifer L; Tate, Jacqueline E; Kirking, Hannah L.
  • McCormick DW; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States; United States Public Health Service, Rockville, MD, United States. Electronic address: yup1@
  • Hagan LM; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Salvatore PP; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States; United States Public Health Service, Rockville, MD, United States. Electronic address: pgx5@cdc.gov.
  • Magleby R; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Lee C; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States; Laboratory Leadership Service, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Sleweon S; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Nicolae L; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Dixon T; Bureau of Prisons, U.S. Department of Justice, Washington, DC, United States.
  • Banta R; Bureau of Prisons, U.S. Department of Justice, Washington, DC, United States.
  • Ogle I; United States Public Health Service, Rockville, MD, United States; Bureau of Prisons, U.S. Department of Justice, Washington, DC, United States.
  • Young C; Bureau of Prisons, U.S. Department of Justice, Washington, DC, United States.
  • Dusseau C; Bureau of Prisons, U.S. Department of Justice, Washington, DC, United States.
  • Ogden C; United States Public Health Service, Rockville, MD, United States; Bureau of Prisons, U.S. Department of Justice, Washington, DC, United States.
  • Browne H; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Michael Metz J; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Chen MH; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Solano MI; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Rogers S; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Burgin A; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Sheth M; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Bankamp B; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Tamin A; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Harcourt JL; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States.
  • Tate JE; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States; United States Public Health Service, Rockville, MD, United States.
  • Kirking HL; COVID-19 Pandemic Response Team, Centers for Disease Control and Prevention, Atlanta, GA, United States; United States Public Health Service, Rockville, MD, United States.
Vaccine ; 2022 Nov 18.
Article in English | MEDLINE | ID: covidwho-2271533
ABSTRACT
The preclinical time course of SARS-CoV-2 shedding is not well-described. Understanding this time course will help to inform risk of SARS-CoV-2 transmission. During an outbreak in a congregate setting, we collected paired mid-turbinate nasal swabs for antigen testing and reverse-transcription polymerase chain reaction (RT-PCR) every other day from all consenting infected and exposed persons. Among 12 persons tested prospectively before and during SARS-CoV-2 infection, ten of 12 participants (83%) had completed a primary COVID-19 vaccination series prior to the outbreak. We recovered SARS-CoV-2 in viral culture from 9/12 (75%) of participants. All three persons from whom we did not recover SARS-CoV-2 in viral culture had completed their primary vaccination series. We recovered SARS-CoV-2 from viral culture in 6/9 vaccinated persons and before symptom onset in 3/6 symptomatic persons. These findings underscore the need for both non-pharmaceutical interventions and vaccination to mitigate transmission.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article