Chapter 23 - Nasal and pulmonary routes of drug delivery
Novel Platforms for Drug Delivery Applications
; : 569-606, 2023.
Article
in English
| ScienceDirect | ID: covidwho-2120338
ABSTRACT
Nasal and pulmonary drug delivery are attractive routes for the administration of a growing number of drugs for topical and systemic treatment as well as for prevention by vaccines. This is of particular interest for drugs with poor bioavailability, as the gastrointestinal passage and hepatic first pass effect can be avoided. The development of drugs, vehicles, and devices made substantial progress. The drug delivery research is focused on transmucosal absorption enhancers such as surfactants, enzyme inhibitors, biopolymers, tight junction modulators, cyclodextrins, and gelling systems and on nasal and pulmonary carrier systems like nanoparticles, microspheres, nano- or microemulsions, and liposomes. Many approaches are still in early development and need further investigation. The trend for devices is going to nasal dry powder inhalers and smart pulmonary nebulizers. A new research area includes inhalable vaccines, biological drugs, and coronavirus treatments.
Full text:
Available
Collection:
Databases of international organizations
Database:
ScienceDirect
Language:
English
Journal:
Novel Platforms for Drug Delivery Applications
Year:
2023
Document Type:
Article
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