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Clinical features of infants with SARS-CoV-2 infection: a systematic review and meta-analysis.
Xiao, Feifan; Tang, Meiling; Yan, Kai; Zhou, Wenhao.
  • Xiao F; Division of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Tang M; Center for Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Department of Pediatrics, Dehong Hospital of Kunming Medical University, Dehong, China.
  • Yan K; Division of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Zhou W; Division of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Center for Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Ann Palliat Med ; 11(11): 3394-3408, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2121906
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19) and is a public health problem. This meta-analysis reviewed the clinical features of SARS-CoV-2 infection among infants.

METHODS:

PubMed, Scopus, Web of Science, and the Cochrane Library were searched for studies on clinical features of infants with SARS-CoV-2 published before May 1, 2022. Two authors screened and extracted data on the number of infants with SARS-CoV-2 infection, clinical features, and number of clinical features. The proportion of asymptomatic infection, mild symptoms, moderate symptoms, severe symptoms, and the clinical features were analyzed.

RESULTS:

Forty-four studies with 6,304 infants with SARS-CoV-2 infections were included in this study. The proportion of asymptomatic infection was 20% (95% CI 11-28%, I2=97%, P<0.01) in infants with SARS-CoV-2 infections. The proportion of infants with mild, moderate, and severe symptoms was 48% (95% CI 30-65%, I2=96%, P<0.01), 27% (95% CI 10-44%, I2=93%, P<0.01), and 8% (95% CI 0-16%, I2=90%, P<0.01), respectively. Notably, the most common clinical features of infants with SARS-CoV-2 infection were fever (64%), cough (34%), and nasal symptoms (31%).

CONCLUSIONS:

This meta-analysis found that 20% of infants with SARS-CoV-2 infections were asymptomatic, while most infants with COVID-19 presented with mild symptoms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans / Infant Language: English Journal: Ann Palliat Med Year: 2022 Document Type: Article Affiliation country: Apm-22-933

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans / Infant Language: English Journal: Ann Palliat Med Year: 2022 Document Type: Article Affiliation country: Apm-22-933