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COVID-19 compromises iron homeostasis: Transferrin as a target of investigation.
Gaiatto, Ana Carolina Macedo; Bibo, Thaciane Alkmim; de Godoy Moreira, Nicolle; Raimundo, Joyce Regina Santos; da Costa Aguiar Alves, Beatriz; Gascón, Thaís; Carvalho, Samantha Sanches; Pereira, Edimar Cristiano; Fonseca, Fernando Luiz Affonso; da Veiga, Glaucia Luciano.
  • Gaiatto ACM; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil.
  • Bibo TA; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil.
  • de Godoy Moreira N; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil.
  • Raimundo JRS; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil.
  • da Costa Aguiar Alves B; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil.
  • Gascón T; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil.
  • Carvalho SS; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil.
  • Pereira EC; Departamento de Ciências Farmacêuticas, UNIFESP, Campus Diadema, Diadema, Brazil.
  • Fonseca FLA; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil; Departamento de Ciências Farmacêuticas, UNIFESP, Campus Diadema, Diadema, Brazil.
  • da Veiga GL; Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André, Brazil. Electronic address: grlveiga@gmail.com.
J Trace Elem Med Biol ; 76: 127109, 2023 Mar.
Article in English | MEDLINE | ID: covidwho-20235752
ABSTRACT
IMPORTANCE Since the beginning of the COVID-19 pandemic, numerous metabolic alterations have been observed in individuals with this disease. It is known that SARS-CoV-2 can mimic the action of hepcidin, altering intracellular iron metabolism, but gaps remain in the understanding of possible outcomes in other pathways involved in the iron cycle.

OBJECTIVE:

To profile iron, ferritin and hepcidin levels and transferrin receptor gene expression in patients diagnosed with COVID-19 between June 2020 and September 2020. DESIGN, SETTING AND

PARTICIPANTS:

Cross-sectional study that evaluated iron metabolism markers in 427 participants, 218 with COVID-19 and 209 without the disease. EXPOSURES The primary exposure was positive diagnose to COVID-19 in general population of Santo André and São Bernardo cities. The positive and negative diagnose were determinate through RT-qPCR. MAIN OUTCOMES AND

MEASURES:

Devido a evidências de alterações do ciclo do ferro em pacientes diagnosticados com COVID-19 e devido a corregulação entre hepcidina e receptor de transferrina, uma análise da expressão gênica deste último, poderia trazer insights sobre o estado de ferro celular. A hipótese foi confirmada, mostrando aumento da expressão de receptor de transferrina concomitante com redução do nível de hepcidina circulante.

RESULTS:

Serum iron presented lower values in individuals diagnosed with COVID-19, whereas serum ferritin presented much higher values in infected patients. Elderly subjects had lower serum iron levels and higher ferritin levels, and men with COVID-19 had higher ferritin values than women. Serum hepcidin was lower in the COVID-19 patient group and transferrin receptor gene expression was higher in the infected patient group compared to controls. CONCLUSIONS AND RELEVANCE COVID-19 causes changes in several iron cycle pathways, with iron and ferritin levels being markers that reflect the state and evolution of infection, as well as the prognosis of the disease. The increased expression of the transferrin receptor gene suggests increased iron internalization and the mimicry of hepcidin action by SARS-CoV-2, reduces iron export via ferroportin, which would explain the low circulating levels of iron by intracellular trapping.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transferrin / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: J Trace Elem Med Biol Journal subject: Metabolism / Environmental Health Year: 2023 Document Type: Article Affiliation country: J.jtemb.2022.127109

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transferrin / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: J Trace Elem Med Biol Journal subject: Metabolism / Environmental Health Year: 2023 Document Type: Article Affiliation country: J.jtemb.2022.127109