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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities.
Rasková, Magdalena; Lacina, Lukás; Kejík, Zdenek; Venhauerová, Anna; Skalicková, Markéta; Kolár, Michal; Jakubek, Milan; Rosel, Daniel; Smetana, Karel; Brábek, Jan.
  • Rasková M; Department of Cell Biology, Faculty of Science, Charles University, 120 00 Prague, Czech Republic.
  • Lacina L; BIOCEV, Faculty of Science, Charles University, 252 50 Vestec, Czech Republic.
  • Kejík Z; Centre for Tumour Ecology, First Faculty of Medicine, Charles University, 120 00 Prague, Czech Republic.
  • Venhauerová A; BIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Czech Republic.
  • Skalicková M; Institute of Anatomy, First Faculty of Medicine, Charles University, 120 00 Prague, Czech Republic.
  • Kolár M; Department of Dermatovenereology, First Faculty of Medicine, Charles University and General University Hospital, 120 00 Prague, Czech Republic.
  • Jakubek M; Centre for Tumour Ecology, First Faculty of Medicine, Charles University, 120 00 Prague, Czech Republic.
  • Rosel D; BIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Czech Republic.
  • Smetana K; Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital, 120 00 Prague, Czech Republic.
  • Brábek J; BIOCEV, Faculty of Science, Charles University, 252 50 Vestec, Czech Republic.
Cells ; 11(22)2022 Nov 21.
Article in English | MEDLINE | ID: covidwho-2123529
ABSTRACT
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-κB) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms / Antineoplastic Agents Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11223698

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms / Antineoplastic Agents Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11223698