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Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2.
Sun, Te-Kai; Huang, Wen-Chin; Sun, Yu-Wen; Deng, Jeng-Shyan; Chien, Liang-Hsuan; Chou, Ya-Ni; Jiang, Wen-Ping; Lin, Jaung-Geng; Huang, Guan-Jhong.
  • Sun TK; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
  • Huang WC; Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung 404, Taiwan.
  • Sun YW; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
  • Deng JS; Department of Food Nutrition and Healthy Biotechnology, Asia University, Taichung 413, Taiwan.
  • Chien LH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
  • Chou YN; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
  • Jiang WP; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan.
  • Lin JG; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
  • Huang GJ; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Int J Mol Sci ; 23(23)2022 Nov 25.
Article in English | MEDLINE | ID: covidwho-2123705
ABSTRACT
The current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of COVID-19 has infected hundreds of millions of people, killed millions, and continues to pose a threat. It has become one of the largest epidemics in human history, causing enormous damage to people's lives and economies in the whole world. However, there are still many uncertainties and continued attention to the impact of SARS-CoV-2 on human health. The entry of SARS-CoV-2 into host cells is facilitated by the binding of the spike protein on the virus surface to the cell surface receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, transmembrane protease serine 2 (TMPRSS2) is a host surface protease that cleaves and proteolytically activates its S protein, which is necessary for viral infection. Thus, SARS-CoV-2 uses the ACE2 receptor for cell entry and initiates the S protein using the protease TMPRSS2. Schizophyllum commune (SC) is one of the most widely distributed fungi, often found on the rotten wood of trees that has been found to have various health benefits, including anticancer, antimicrobial activity, antiparasitic, and immunomodulatory function. In this article, SC significantly diminished the expression ACE2 and TMPRSS2 protein in vitro and in vivo without cell damage. In addition, adenosine from SC was also proven in this experiment to reduce the ACE2 and TMPRSS2 expression. Thus, our findings suggest that SC and adenosine exhibit potential for the repression of SARS-CoV-2 infection via the ACE2 and TMPRSS2 axis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Schizophyllum / Biological Products / Serine Endopeptidases / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms232314766

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Schizophyllum / Biological Products / Serine Endopeptidases / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms232314766