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Citrus junos Tanaka Peel Extract Ameliorates HDM-Induced Lung Inflammation and Immune Responses In Vivo.
Shim, Dahee; Kim, Hwa-Jin; Lee, Jungu; Lee, You-Min; Park, Jae-Woong; Yang, Siyoung; Lee, Gyeong-Hweon; Chung, Myoung Ja; Chae, Han-Jung.
  • Shim D; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute & Non-Clinical Evaluation Center, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.
  • Kim HJ; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute & Non-Clinical Evaluation Center, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.
  • Lee J; Lotte R&D Center, Seoul 07594, Republic of Korea.
  • Lee YM; Lotte R&D Center, Seoul 07594, Republic of Korea.
  • Park JW; Lotte R&D Center, Seoul 07594, Republic of Korea.
  • Yang S; Lotte R&D Center, Seoul 07594, Republic of Korea.
  • Lee GH; Lotte R&D Center, Seoul 07594, Republic of Korea.
  • Chung MJ; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54907, Republic of Korea.
  • Chae HJ; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute & Non-Clinical Evaluation Center, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.
Nutrients ; 14(23)2022 Nov 25.
Article in English | MEDLINE | ID: covidwho-2123778
ABSTRACT
In the wake of the COVID-19 pandemic, lung disorders have become a major health concern for humans. Allergic asthma is the most prevalent form of asthma, and its treatments target the inflammation process. Despite significant developments in the diagnosis and management of allergic asthma, side effects are a major concern. Additionally, its extreme heterogeneity impedes the efficacy of the majority of treatments. Thus, newer, safer therapeutic substances, such as natural products, are desired. Citrus junos Tanaka has traditionally been utilized as an anti-inflammatory, sedative, antipyretic, and antitoxic substance. In this study, the protective effects of Citrus junos Tanaka peel extract (B215) against lung inflammation were examined, and efforts were made to understand the underlying protective mechanism using an HDM-induced lung inflammation murine model. The administration of B215 reduced immune cell infiltration in the lungs, plasma IgE levels, airway resistance, mucus hypersecretions, and cytokine production. These favorable effects alleviated HDM-induced lung inflammation by modulating the NF-κB signaling pathway. Hence, B215 might be a promising functional food to treat lung inflammation without adverse effects.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Asthma / Citrus / COVID-19 Limits: Animals / Humans Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Asthma / Citrus / COVID-19 Limits: Animals / Humans Language: English Year: 2022 Document Type: Article