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Impact of Zinc, Vitamins C and D on Disease Prognosis among Patients with COVID-19 in Bangladesh: A Cross-Sectional Study.
Sharif, Nadim; Opu, Rubayet Rayhan; Khan, Afsana; Alzahrani, Khalid J; Banjer, Hamsa Jameel; Alzahrani, Fuad M; Haque, Nusaira; Khan, Shahriar; Soumik, Saimum Tahreef; Zhang, Ming; Huang, Hanwen; Song, Xiao; Parvez, Anowar Khasru; Dey, Shuvra Kanti.
  • Sharif N; Department of Microbiology, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Opu RR; Department of Microbiology, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Khan A; Department of Statistics, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Alzahrani KJ; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
  • Banjer HJ; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
  • Alzahrani FM; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
  • Haque N; Department of Microbiology, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Khan S; Department of Microbiology, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Soumik ST; Department of Microbiology, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Zhang M; Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA.
  • Huang H; Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA.
  • Song X; Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA.
  • Parvez AK; Department of Microbiology, Jahangirnagar University, Dhaka 1342, Bangladesh.
  • Dey SK; Department of Microbiology, Jahangirnagar University, Dhaka 1342, Bangladesh.
Nutrients ; 14(23)2022 Nov 26.
Article in English | MEDLINE | ID: covidwho-2123779
ABSTRACT
Vitamin C, (ascorbic acid), vitamin D (cholecalciferol) and zinc (zinc sulfate monohydrate) supplements are important in immunity against coronavirus disease-2019 (COVID-19). However, a limited number of studies have been conducted on the association of vitamins and supplements with the reduced risks of COVID-19 infection. This study aims to evaluate the association of vitamins and supplements as treatment options to reduce the severity of COVID-19. Data were collected from 962 participants from 13 December 2020 to 4 February 2021. The presence of COVID-19 was confirmed by qRT-PCR. The Chi-square test and multivariate regression analyses were conducted. The ratio of uptake of vitamin Cvitamin Dzinc was 110.95. Uptake of vitamin C, vitamin D and zinc were significantly associated with the reduced risk of infection and severity of COVID-19 (OR 0.006 (95% CI 0.03-0.11) (p = 0.004)) and (OR 0.03 (95% CI 0.01-0.22) (p = 0.005)). The tendency of taking supplements was associated with the presence of infection of COVID-19 (p = 0.001), age (p = 0.02), sex (p = 0.05) and residence (p = 0.04). The duration of supplementation and medication was significantly associated with reduced hospitalization (p = 0.0001). Vitamins C, D and zinc were not significantly (p = 0.9) associated with a reduced risk of severity when taken through the diet. Hospitalization (p = 0.000001) and access to health facilities (p = 0.0097) were significantly associated with the survival period of the participants. Participants with better access to health facilities recovered early (OR 6.21, 95% CI 1.56-24.7). This study will add knowledge in the field of treatment of COVID-19 by using vitamins and zinc supplements.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ascorbic Acid / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14235029

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ascorbic Acid / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14235029