Safety Concerns Of Drugs And Vaccines Used In The Treatment Of COVID-19

ABSTRACT

The Novel Coronavirus disease 2019 pandemic which is named as COVID-19 or '2019 n CoV ' or 2019 novel coronavirus by WHO is a highly contagious viral respiratory disease caused due to SARS- CoV-2. Various drugs used to treat this pandemic are Hydroxychloroquine, Remdesivir, Favipiravir, Dexamethasone, etc. These drugs are effective, but they have also shown adverse drug reactions (ADRs) during the treatment of COVID-19 and when an ADR arises due to their use, they add an additional level of complexity in the management of COVID-19 disease. This review aims to demonstrate the mechanism of action as well as the safety issues associated with the drugs used for COVID-19. It also focuses on the safety issues related with two vaccines manufactured by Pfizer and AstraZeneca, respectively. A comprehensive search in PubMed, Science direct, Drug bank, PubChem, CDC, WHO, FDA database was accomplished for research regarding ADR case reports associated with the drugs and vaccines for COVID-19.