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Regen-COV-2 Antibody Cocktail Mediated Clearance of SARS-COV-2 in an Immunocompromised Patient.
Basheer, Maamoun; Saad, Elias; Milhem, Faris; Budman, Dmitry; Assy, Nimer.
  • Basheer M; Department of Internal Medicine, Galilee Medical Center, Nahariya, Israel, Biotechnology and Radiology Laboratory, Hadassah Medical Organization and Faculty of Medicine.
  • Saad E; Department of Internal Medicine, Galilee Medical Center, Nahariya, Israel, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Milhem F; Department of Internal Medicine, Galilee Medical Center, Nahariya, Israel.
  • Budman D; Department of Internal Medicine, Galilee Medical Center, Nahariya, Israel.
  • Assy N; Department of Internal Medicine, Galilee Medical Center, Nahariya, Israel, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Isr Med Assoc J ; 24(11): 695-696, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2124642
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) affects different people in different ways. Most infected people develop mild to moderate illness and recover without hospitalization. This case report presents a patient who had difficulty eradicating the corona virus due to being treated with rituximab, which depletes B lymphocytes and therefore disables the production of neutralizing antibodies. The regen-COV-2 antibody cocktail consists of two monoclonal antibodies, casirivimab and imdevimab. This cocktail successfully helped the patient's immune system eradicate the virus without auto specific severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody production. In vitro studies confirm that eradication of the intact the virus. This case report emphases the importance of providing external antiviral antibodies regularly, like the regen-COV-2 antibody cocktail, as post- and even pre- SARS-CoV-2 infection prophylaxis in patients treated with rituximab.
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Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Experimental Studies Limits: Humans Language: English Journal: Isr Med Assoc J Journal subject: Medicine Year: 2022 Document Type: Article

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Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Experimental Studies Limits: Humans Language: English Journal: Isr Med Assoc J Journal subject: Medicine Year: 2022 Document Type: Article