A Study of ESRD Patients on Maintenance Haemodialysis With COVID-19

ABSTRACT

Background: This study presents the data of ESRD patients on maintenance haemodialysis (MHD) with COVID-19 disease from Sri Padmavathi Medical College (SPMC) Hospital, SVIMS University, Andhra Pradesh, India which had been ordained as the State COVID Hospital in March 2020. Method(s) We collected the data from March 2020 to December 2021 of ESRD patients on MHD in a retrospective observational study and identified the risk factors for mortality. Result(s) At SPMC Hospital, the total number of COVID-19 disease patients managed was 15,719. The number of deaths reported was 2,878 (18.3%). We idenfited a total of 714 ESRD patients who required MHD during this period. We analyzed data for 595 patients (83.3%). The rest of patient files could not be traced owing to mismatch in the medical record numbers and patient names. The number of ESRD patients on MHD with COVID-19 disease who died were 203 out of 595 (34.1%). We identified age, SpO2 at admission, number of dialysis sessions, total leucocyte count, neutrophils, lymphocytes, blood urea, serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), C-reactive protein (CRP), serum ferritin, serum lactate dehydrogenase (LDH), male, diabetes mellitus, oxygen requirement at admission, non invasive ventilation (NIV) at admission and NIV in hospital as significant risk factors for mortality (P<0.001). On multivariate analysis age, NIV during hospital stay and serum LDH returned significant. Conclusion(s) The mortality rate in ESRD patients on MHD with COVID-19 disease at our institution was not divergent from the published studies;however, we identified several different risk factors.