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Association of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness.
Wisk, Lauren E; Gottlieb, Michael A; Spatz, Erica S; Yu, Huihui; Wang, Ralph C; Slovis, Benjamin H; Saydah, Sharon; Plumb, Ian D; O'Laughlin, Kelli N; Montoy, Juan Carlos C; McDonald, Samuel A; Lin, Zhenqiu; Lin, Jin-Mann S; Koo, Katherine; Idris, Ahamed H; Huebinger, Ryan M; Hill, Mandy J; Gentile, Nicole L; Chang, Anna Marie; Anderson, Jill; Hota, Bala; Venkatesh, Arjun K; Weinstein, Robert A; Elmore, Joann G; Nichol, Graham.
  • Wisk LE; Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles.
  • Gottlieb MA; Department of Health Policy and Management, Fielding School of Public Health at the University of California, Los Angeles, Los Angeles.
  • Spatz ES; Department of Emergency Medicine, Rush University Medical Center, Chicago, Illinois.
  • Yu H; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
  • Wang RC; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.
  • Slovis BH; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
  • Saydah S; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.
  • Plumb ID; Department of Emergency Medicine, University of California, San Francisco, San Francisco.
  • O'Laughlin KN; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Montoy JCC; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • McDonald SA; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Lin Z; Department of Emergency Medicine, University of Washington, Seattle.
  • Lin JS; Department of Global Health, University of Washington, Seattle.
  • Koo K; Department of Emergency Medicine, University of California, San Francisco, San Francisco.
  • Idris AH; Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas.
  • Huebinger RM; Clinical Informatics Center, University of Texas Southwestern Medical Center, Dallas.
  • Hill MJ; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
  • Gentile NL; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut.
  • Chang AM; National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Anderson J; Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
  • Hota B; Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas.
  • Venkatesh AK; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
  • Weinstein RA; Department of Emergency Medicine, McGovern Medical School, UTHealth Houston, Houston, Texas.
  • Elmore JG; Department of Emergency Medicine, McGovern Medical School, UTHealth Houston, Houston, Texas.
  • Nichol G; Department of Family Medicine, University of Washington, Seattle.
JAMA Netw Open ; 5(12): e2244486, 2022 Dec 01.
Article in English | MEDLINE | ID: covidwho-2127465
ABSTRACT
Importance Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use.

Objective:

To compare patient-reported outcomes of physical, mental, and social well-being among adults with symptomatic illness who received a positive vs negative test result for SARS-CoV-2 infection. Design, Setting, and

Participants:

This cohort study was a planned interim analysis of an ongoing multicenter prospective longitudinal registry study (the Innovative Support for Patients With SARS-CoV-2 Infections Registry [INSPIRE]). Participants were enrolled from December 11, 2020, to September 10, 2021, and comprised adults (aged ≥18 years) with acute symptoms suggestive of SARS-CoV-2 infection at the time of receipt of a SARS-CoV-2 test approved by the US Food and Drug Administration. The analysis included the first 1000 participants who completed baseline and 3-month follow-up surveys consisting of questions from the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29; 7 subscales, including physical function, anxiety, depression, fatigue, social participation, sleep disturbance, and pain interference) and the PROMIS Short Form-Cognitive Function 8a scale, for which population-normed T scores were reported. Exposures SARS-CoV-2 status (positive or negative test result) at enrollment. Main Outcomes and

Measures:

Mean PROMIS scores for participants with positive COVID-19 tests vs negative COVID-19 tests were compared descriptively and using multivariable regression analysis.

Results:

Among 1000 participants, 722 (72.2%) received a positive COVID-19 result and 278 (27.8%) received a negative result; 406 of 998 participants (40.7%) were aged 18 to 34 years, 644 of 972 (66.3%) were female, 833 of 984 (84.7%) were non-Hispanic, and 685 of 974 (70.3%) were White. A total of 282 of 712 participants (39.6%) in the COVID-19-positive group and 147 of 275 participants (53.5%) in the COVID-19-negative group reported persistently poor physical, mental, or social well-being at 3-month follow-up. After adjustment, improvements in well-being were statistically and clinically greater for participants in the COVID-19-positive group vs the COVID-19-negative group only for social participation (ß = 3.32; 95% CI, 1.84-4.80; P < .001); changes in other well-being domains were not clinically different between groups. Improvements in well-being in the COVID-19-positive group were concentrated among participants aged 18 to 34 years (eg, social participation ß = 3.90; 95% CI, 1.75-6.05; P < .001) and those who presented for COVID-19 testing in an ambulatory setting (eg, social participation ß = 4.16; 95% CI, 2.12-6.20; P < .001). Conclusions and Relevance In this study, participants in both the COVID-19-positive and COVID-19-negative groups reported persistently poor physical, mental, or social well-being at 3-month follow-up. Although some individuals had clinically meaningful improvements over time, many reported moderate to severe impairments in well-being 3 months later. These results highlight the importance of including a control group of participants with negative COVID-19 results for comparison when examining the sequelae of COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: North America Language: English Journal: JAMA Netw Open Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: North America Language: English Journal: JAMA Netw Open Year: 2022 Document Type: Article