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Fulminant myocarditis with COVID-19 infection having normal C-reactive protein and serial magnetic resonance follow-up.
Usui, Eisuke; Nagaoka, Eiki; Ikeda, Hiroshi; Ohmori, Mari; Tao, Susumu; Yonetsu, Taishi; Maejima, Yasuhiro; Arai, Hirokuni; Amemiya, Kisaki; Ikeda, Yoshihiko; Sasano, Tetsuo.
  • Usui E; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, Japan.
  • Nagaoka E; Department of Cardiovascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ikeda H; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, Japan.
  • Ohmori M; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, Japan.
  • Tao S; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, Japan.
  • Yonetsu T; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, Japan.
  • Maejima Y; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, Japan.
  • Arai H; Department of Cardiovascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
  • Amemiya K; Department of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan.
  • Ikeda Y; Department of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan.
  • Sasano T; Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, Japan.
ESC Heart Fail ; 2022 Nov 19.
Article in English | MEDLINE | ID: covidwho-2284959
ABSTRACT
A 44-year-old woman who was quarantined for 5 days after the diagnosis of coronavirus disease of 2019 (COVID-19) was transferred to our hospital with the complaint of chest pain. The patient was unvaccinated. Electrocardiography revealed ST elevation in the lateral leads. Echocardiographic biventricular dysfunction with oedematous wall thickening was identified. Cardiac enzyme levels were elevated; however, C-reactive protein (CRP) levels, and the coronary angiogram were normal. The patient required mechanical circulatory support to stabilize haemodynamics and was treated with remdesivir, baricitinib, and intravenous methylprednisolone. She recovered after 13 days of mechanical support. Serial cardiac magnetic resonance imaging revealed acute myocardial oedema and subsequent fibrosis. An endomyocardial biopsy on admission showed mild interstitial inflammatory infiltrates with endomyocardial fibrous thickening and mild interstitial fibrosis of the myocardium. Normal CRP levels suggested minor involvement of interleukin (IL)-6, supporting the efficacy of baricitinib.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Ehf2.14228

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Cohort study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Ehf2.14228