No difference in the management of Covid-19 hemophilic and non-hemophilic patients

ABSTRACT

Background: Several guidelines specifically suggest how to manage hemophilic patients (PWH) with COVID-19, but recent studies have shown that Covid-19 PWH management does not differ from the general population Aims: To evaluate our COVID-19 PWH to confirm if this trend is also present in our Centre Methods: We retrospectively evaluated data about 8 Covid-19 PWH (4 adults and 4 pediatrics) during 2020-22. Median age was 28.7 (range 10-61). 5 were hemophilic A (2 severe and 3 moderate), 3 were severe B (one inhibitor). At the moment of observation 6 they had not yet been vaccinated, two had received the second and third doses respectively Results: Only one 56-year- old patient needed hospitalization He presented diabetes, hypertension, hepatitis C and prostatic hypertrophy and was admitted to the hospital because of a worsening dyspnea, and was treated with noninvasive ventilation. Heparin was avoided because of the hemorrhagic risk and the other therapies were administered orally or intravenously. He was discharged after 7 days. Of the other adults, a 27-year- old man manifested mild dyspnea and diarrhea without needing hospitalization.The 34-year- old who had received the two doses of vaccine scheduled at that time did not show any symptomatology. The 61-year- old with three doses of vaccine, developed mild symptoms (low grade fever, sore throat, mild muscle pains). All 4 pediatric patients were successfully treated at homeonly the inhibitor patient had an episode of nosebleed treated with single by-passant treatment;the pediatric PWH reported mild symptoms Low-grade fever, asthenia, headache, cold and cough;one had a temporary anosmia and ageusia. Results are resumed in table 1 Conclusion(s) Our experience showed no difference between PWH and the general population The only adult who needed hospitalization was the one with comorbidities and for whom the application of Guidelines for Covid-19 PWH avoided bleedings.The pediatric patients and the vaccinated adults were pauci-symptomatic and were cured at home.