Your browser doesn't support javascript.
Investigation of thrombin generation in COVID-19 patients by a care setting design
Research and Practice in Thrombosis and Haemostasis Conference ; 6(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2128265
ABSTRACT

Background:

The coagulation system showed significant variations in COVID-19 patients. These variations may parallel the disease stage of COVID-19 toward either a hyper-activation or coagulopathy syndrome. Classical clotting tests assist in exploring coagulation disorders, but they are unsuitable to examine prothrombotic conditions. In this regard, thrombin generation assay helps for a global assessment of the coagulation process, being appropriate for investigating hypercoagulable states and bleeding tendency. Aim(s) It was investigated whether thrombin generation assay reveals coagulation variations in COVID-19 patients by a care setting design. Method(s) From October to December 2020, it have been enrolled 27 and 40 patients with a confirmed COVID-19 diagnosis who were hospitalised in an Intensive Care Unit (ICU) and a Medical Ward (MW), respectively. Also, 34 healthy subjects were included in this study. Thrombin generation parameters were evaluated using a Calibrated Automated Thrombogram system. Informed consent and approval by the local medical Ethics Committee were obtained. Result(s) Lag-Time and time-to- peak found in ICU and MW patients were significantly higher than those found in healthy subjects (Kruskal-Wallis test P < 0.0001). Endogenous-Thrombin- Potential and thrombin-peak observed in ICU and MW patients were significantly lower than those observed in healthy subjects (Kruskal-Wallis test P < 0.0001). No statistically significant differences in all the parameters measured were observed between ICU and MW patients. Conclusion(s) Thrombin generation assay performed in this study evidenced an acquired coagulopathy in COVID-19 patients that, however, seems to be unrelated to the care setting and, in turn, to the clinical disease severity.
Keywords

Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Research and Practice in Thrombosis and Haemostasis Conference Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Research and Practice in Thrombosis and Haemostasis Conference Year: 2022 Document Type: Article