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Level of coagulation aberrations among COVID-19 patients in Ethiopia, Findings from the Horn of Africa
Research and Practice in Thrombosis and Haemostasis Conference ; 6(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2128296
ABSTRACT

Background:

Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. Aim(s) To analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia, the Horn of Africa. Method(s) This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID 19 care and treatment center, Addis Ababa, Ethiopia from July 1-October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOTDUEPLUS coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p < 0.05 was defined as statistically significant. Result(s) A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients.Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. Conclusion(s) Inthisstudy, prolonged prothrombin time and elevated INR were detected in morethan 50% of severe and critical COVID-19 patients.Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients olderthan 55 years.Thus, were commendemphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Research and Practice in Thrombosis and Haemostasis Conference Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Research and Practice in Thrombosis and Haemostasis Conference Year: 2022 Document Type: Article