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Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort.
Schild, Ann-Katrin; Goereci, Yasemin; Scharfenberg, Daniel; Klein, Kim; Lülling, Joachim; Meiberth, Dix; Schweitzer, Finja; Stürmer, Sophie; Zeyen, Philip; Sahin, Derya; Fink, Gereon R; Jessen, Frank; Franke, Christiana; Onur, Oezguer A; Kessler, Josef; Warnke, Clemens; Maier, Franziska.
  • Schild AK; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany. ann-katrin.schild@uk-koeln.de.
  • Goereci Y; Department of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Scharfenberg D; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Klein K; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Lülling J; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Meiberth D; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Schweitzer F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Stürmer S; Department of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Zeyen P; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Sahin D; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Fink GR; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Jessen F; Department of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Franke C; Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich, Jülich, Germany.
  • Onur OA; Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Kessler J; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Warnke C; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Maier F; Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
J Neurol ; 2022 Nov 23.
Article in English | MEDLINE | ID: covidwho-2280116
ABSTRACT

BACKGROUND:

A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients.

METHODS:

Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered.

RESULTS:

Of the 58 patients screened, six were excluded due to possible alternative causes of cognitive impairment (major depression, neurodegenerative disease). Of the remaining 52 individuals, only one had a below-threshold screening result on Mini-Mental State Examination, and 13 scored below the cut-off on Montreal Cognitive Assessment. Extended neuropsychological testing revealed a neurocognitive disorder (NCD) in 31 (59.6%) participants with minor NCD in the majority of cases (n = 26). In patients with NCD, the cognitive domains learning/memory and executive functions were impaired in 60.7%, complex attention in 51.6%, language in 35.5%, and perceptual-motor function in 29.0%. Cognitive profiles were associated with daytime sleepiness but not with depression, anxiety, sleep quality, total general health status, or fatigue.

CONCLUSION:

Neurocognitive impairment can be confirmed in around 60% of individuals with self-reported deficits as part of post-COVID-19 syndrome following a mild acute COVID-19 disease course. Notably, screening tests cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association with cognitive profiles. Longitudinal studies are needed to further evaluate the course of neurocognitive deficits and clarify pathophysiology.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: S00415-022-11444-w

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: S00415-022-11444-w