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Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses.
Ogata, Alana F; Lazarovits, Roey; Uwamanzu-Nna, Augusta; Gilboa, Tal; Cheng, Chi-An; Walt, David R.
  • Ogata AF; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, 3 Blackfan Cir, Harvard University, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
  • Lazarovits R; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, 3 Blackfan Cir, Harvard University, Boston, MA 02115, USA.
  • Uwamanzu-Nna A; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02215, USA.
  • Gilboa T; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, 3 Blackfan Cir, Harvard University, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
  • Cheng CA; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, 3 Blackfan Cir, Harvard University, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
  • Walt DR; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, 3 Blackfan Cir, Harvard University, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address: dwalt@bwh.h
Clin Lab Med ; 42(1): 97-109, 2022 03.
Article in English | MEDLINE | ID: covidwho-2130422
ABSTRACT
Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and the receptor-binding domain as targets of antibody responses. They highlight serologic studies during acute SARS-CoV-2 infection and discuss the clinical relevance of antibody levels in COVID-19 progression. Antibody responses in pediatric COVID-19 patients are also reviewed. Finally, the authors discuss antibody responses during convalescence and their role in protection from SARS-CoV-2 reinfection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Child / Humans Language: English Journal: Clin Lab Med Year: 2022 Document Type: Article Affiliation country: J.cll.2021.10.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Child / Humans Language: English Journal: Clin Lab Med Year: 2022 Document Type: Article Affiliation country: J.cll.2021.10.002