IN VITRO AND IN VIVO MODELS FOR MONKEYPOX.
iScience
; : 105702, 2022 Dec 01.
Article
in English
| MEDLINE | ID: covidwho-2244688
ABSTRACT
The emergence and rapid spread outside of monkeypox virus (MPXV) to nonendemic areas has led to another global health emergency in the midst of the COVID-19 pandemic. The scientific community has sought to rapidly develop in vitro and in vivo models that could be applied in research with MPXV. In vitro models include two-dimensional (2D) cultures of immortalized cell lines or primary cells and three-dimensional (3D) cultures. In vitro models are considered cost-effective and can done in highly controlled conditions, however, they do not always resemble physiological conditions. In this way, several in vivo models are being characterized to meet the growing demand for new studies related to MPXV. In this review, we summarize the main MPXV models that have already been developed and discuss how they can contribute to the advance the understanding of its pathogenesis, replication, and transmission, as well as identifying antivirals to treat infected patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
Language:
English
Journal:
IScience
Year:
2022
Document Type:
Article
Affiliation country:
J.isci.2022.105702
Similar
MEDLINE
...
LILACS
LIS