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Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.
Liu, Jia Li; Woo, Jennifer M P; Parks, Christine G; Costenbader, Karen H; Jacobsen, Søren; Bernatsky, Sasha.
  • Liu JL; McGill University, Montreal, Quebec, Canada.
  • Woo JMP; Epidemiology Branch, Department of Health and Human Services, National Institutes of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
  • Parks CG; Epidemiology Branch, Department of Health and Human Services, National Institutes of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
  • Costenbader KH; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Jacobsen S; Copenhagen Lupus and Vasculitis Clinic, Rigshospitalet, Copenhagen University Hospital, Denmark.
  • Bernatsky S; Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: sasha.bernatsky@mcgill.ca.
Rheum Dis Clin North Am ; 48(4): 827-843, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2232614
ABSTRACT
Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease. The etiology of SLE is multifactorial and includes potential environmental triggers, which may occur sequentially (the "multi-hit" hypothesis). This review focuses on SLE risk potentially associated with environmental factors including infections, the microbiome, diet, respirable exposures (eg, crystalline silica, smoking, air pollution), organic pollutants, heavy metals, and ultraviolet radiation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Environmental Exposure / Lupus Erythematosus, Systemic Type of study: Etiology study / Observational study / Prognostic study Limits: Humans Language: English Journal: Rheum Dis Clin North Am Journal subject: Rheumatology Year: 2022 Document Type: Article Affiliation country: J.rdc.2022.06.005

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Environmental Exposure / Lupus Erythematosus, Systemic Type of study: Etiology study / Observational study / Prognostic study Limits: Humans Language: English Journal: Rheum Dis Clin North Am Journal subject: Rheumatology Year: 2022 Document Type: Article Affiliation country: J.rdc.2022.06.005