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Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples.
Liechti, Thomas; Iftikhar, Yaser; Mangino, Massimo; Beddall, Margaret; Goss, Charles W; O'Halloran, Jane A; Mudd, Philip A; Roederer, Mario.
  • Liechti T; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Maryland, 20892, USA. liechti.thom@gmail.com.
  • Iftikhar Y; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Maryland, 20892, USA.
  • Mangino M; Department of Twin Research & Genetic Epidemiology, King's College of London, London, UK.
  • Beddall M; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK.
  • Goss CW; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Maryland, 20892, USA.
  • O'Halloran JA; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  • Mudd PA; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Roederer M; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Nat Commun ; 13(1): 7255, 2022 Nov 25.
Article in English | MEDLINE | ID: covidwho-2133429
ABSTRACT
Severe COVID-19 causes profound immune perturbations, but pre-infection immune signatures contributing to severe COVID-19 remain unknown. Genome-wide association studies (GWAS) identified strong associations between severe disease and several chemokine receptors and molecules from the type I interferon pathway. Here, we define immune signatures associated with severe COVID-19 using high-dimensional flow cytometry. We measure the cells of the peripheral immune system from individuals who recovered from mild, moderate, severe or critical COVID-19 and focused only on those immune signatures returning to steady-state. Individuals that suffered from severe COVID-19 show reduced frequencies of T cell, mucosal-associated invariant T cell (MAIT) and dendritic cell (DC) subsets and altered chemokine receptor expression on several subsets, such as reduced levels of CCR1 and CCR2 on monocyte subsets. Furthermore, we find reduced frequencies of type I interferon-producing plasmacytoid DCs and altered IFNAR2 expression on several myeloid cells in individuals recovered from severe COVID-19. Thus, these data identify potential immune mechanisms contributing to severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34638-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34638-2