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Strong anti-viral nano biocide based on Ag/ZnO modified by amodiaquine as an antibacterial and antiviral composite.
Dolatyari, Mahboubeh; Rostami, Ali.
  • Dolatyari M; Industrial Park of Advanced Technologies, ASEPE Company, Tabriz, 5364196795, Iran.
  • Rostami A; Industrial Park of Advanced Technologies, ASEPE Company, Tabriz, 5364196795, Iran. rostami@tabrizu.ac.ir.
Sci Rep ; 12(1): 19934, 2022 Nov 19.
Article in English | MEDLINE | ID: covidwho-2133627
ABSTRACT
In this paper, we synthesized Ag/ZnO composite colloidal nanoparticles and the surface of nanoparticles was improved by amodiaquine ligand. The synthesized nanoparticles were characterized using the XRD diffraction pattern, FT-IR Spectroscopy, TEM image, and UV-Vis spectroscopy. The antibacterial, antifungal, and antiviral effects of the synthesized colloid were examined on E.coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus hirae bacteria, and Candida Albicans and form spore aspergillus fungi, also influenza, herpes simplex, and covid 19 viruses. The results indicate more than 7 log removal of the bacteria, fungi, and viruses by synthesized colloid with a concentration of 15 µg/L (Ag)/50 µg/ml (ZnO). This removal for covid 19 virus is from 3.2 × 108 numbers to 21 viruses within 30 s. Also, irritation and toxicity tests of the synthesized colloid show harmless effects on human cells and tissues. These colloidal nanoparticles were used as mouthwash solution and their clinical tests were done on 500 people infected by the coronavirus. The results indicate that by washing their mouth and nose three times on day all patients got healthy at different times depending on the depth of the disease. Almost all people with no signs of infection and using this solution as a mouthwash didn't infect by the virus during the study.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc Oxide / Disinfectants / Metal Nanoparticles / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-24540-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc Oxide / Disinfectants / Metal Nanoparticles / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-24540-8