Your browser doesn't support javascript.
Neuro-ophthalmological Presentation of Optic Neuritis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Lin, Ting-Yi; Asseyer, Susanna; Buenrostro, Gilberto Solorza; Feldmann, Kristina; Hamann, Steffen; Paul, Friedemann; Zimmermann, Hanna G.
  • Lin TY; Experimental and Clinical Research Center, A Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Asseyer S; Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  • Buenrostro GS; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany.
  • Feldmann K; Experimental and Clinical Research Center, A Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Hamann S; Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  • Paul F; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany.
  • Zimmermann HG; Experimental and Clinical Research Center, A Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Klin Monbl Augenheilkd ; 239(11): 1305-1314, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2133759
ABSTRACT
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare demyelinating autoimmune disorder of the central nervous system. MOGAD frequently manifests with severe, bilateral, and episodes of recurrent optic neuritis (ON) and is an important differential diagnosis to multiple sclerosis and aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorders. Besides ON, the clinical manifestations of MOGAD commonly include transverse myelitis, acute disseminated encephalomyelitis, and brain stem encephalitis. In this review, we summarize the current knowledge of the neuro-ophthalmological presentation of MOGAD-ON. We describe epidemiological aspects, including the association with COVID-19 and other infections or vaccinations, clinical presentation, and imaging findings of MOGAD-ON in the acute stage and during remission. Furthermore, we report findings on prognosis, treatment response, and changes in ON-unaffected eyes. We touch upon findings on visual acuity, visual fields, and visual evoked potentials, as well as structural changes assessed with optical coherence tomography. Moreover, we explain how to differentiate MOGAD from its differential diagnoses, including other neuroinflammatory disorders (multiple sclerosis and neuromyelitis optica spectrum disorders), but also idiopathic intracranial hypertension.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Optic Neuritis / Neuromyelitis Optica / COVID-19 / Multiple Sclerosis Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Klin Monbl Augenheilkd Year: 2022 Document Type: Article Affiliation country: A-1928-5117

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Optic Neuritis / Neuromyelitis Optica / COVID-19 / Multiple Sclerosis Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Klin Monbl Augenheilkd Year: 2022 Document Type: Article Affiliation country: A-1928-5117