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Lung Abnormalities in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: An Analysis of Paired Computed Tomography Scans Before and After Infection.
Iversen, Katrine K; Ronit, Andreas; Kristensen, Thomas S; Afzal, Shoaib; Jankovic, Jelena; Kalhauge, Anna; Ahlström, Magnus G; Nordestgaard, Børge G; Kofoed, Klaus F; Benfield, Thomas.
  • Iversen KK; Department of Infectious Diseases 144, Copenhagen University Hospital-Amager Hvidovre, Hvidovre, Denmark.
  • Ronit A; Department of Infectious Diseases 144, Copenhagen University Hospital-Amager Hvidovre, Hvidovre, Denmark.
  • Kristensen TS; Department of Radiology and Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Afzal S; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
  • Jankovic J; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Kalhauge A; The Copenhagen General Population Study, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
  • Ahlström MG; Department of Radiology and Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Nordestgaard BG; Department of Radiology and Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Kofoed KF; Department of Clinical Microbiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Benfield T; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
Open Forum Infect Dis ; 9(11): ofac596, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2135527
ABSTRACT

Background:

Studies on the pulmonary consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are impeded by limited access to pre-SARS-CoV-2 examinations.

Methods:

We invited Copenhagen General Population Study participants with a confirmed SARS-CoV-2 polymerase chain reaction (PCR) test during the first and second coronavirus disease 2019 waves in Denmark for a repeat chest computed tomography (CT) scan. Paired CT scans were independently assessed for interstitial and noninterstitial abnormalities by 2 trained radiologists. A semiquantitative CT score (ranging from 0 to 20) was used to quantify the extent of interstitial abnormalities.

Results:

Of 111 SARS-CoV-2-infected individuals, 102 (91.2%) experienced symptoms and 12 (11.2%) were hospitalized. Follow-up examination was performed at median of 5.4 (interquartile range, 4.1-7.8) months after a positive SARS-CoV-2 PCR test. Of 67 individuals with paired CT scans, ground glass opacities and reticulation were present in 31 (46.3%) individuals post-SARS-CoV-2 compared to 23 (34.1%) pre-SARS-CoV-2 (mean CT score, 3.0 vs 1.3; P = .011). Results were similar for nonhospitalized individuals. We did not detect development of bronchiectasis, emphysema, or nodules.

Conclusions:

SARS-CoV-2 infection in predominantly nonhospitalized individuals with mild disease was associated with a small increase in only interstitial lung abnormalities.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid