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Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later.
Milligan, Emma C; Olstad, Katherine; Williams, Caitlin A; Mallory, Michael; Cano, Patricio; Cross, Kaitlyn A; Munt, Jennifer E; Garrido, Carolina; Lindesmith, Lisa; Watanabe, Jennifer; Usachenko, Jodie L; Hopkins, Lincoln; Immareddy, Ramya; Lakshmanappa, Yashavanth Shaan; Elizaldi, Sonny R; Roh, Jamin W; Sammak, Rebecca L; Pollard, Rachel E; Yee, JoAnn L; Herbek, Savannah; Scobey, Trevor; Miehlke, Dieter; Fouda, Genevieve; Ferrari, Guido; Gao, Hongmei; Shen, Xiaoying; Kozlowski, Pamela A; Montefiori, David; Hudgens, Michael G; Edwards, Darin K; Carfi, Andrea; Corbett, Kizzmekia S; Graham, Barney S; Fox, Christopher B; Tomai, Mark; Iyer, Smita S; Baric, Ralph; Reader, Rachel; Dittmer, Dirk P; Van Rompay, Koen K A; Permar, Sallie R; De Paris, Kristina.
  • Milligan EC; Department of Microbiology and Immunology, Children's Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Olstad K; California National Primate Research Center, University of California at Davis, Davis, California 95616, USA.
  • Williams CA; Department of Pediatrics, Weill Cornell Medical College, NY, New York 10065, USA.
  • Mallory M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Cano P; Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Cross KA; Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Munt JE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Garrido C; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, California 95616, USA.
  • Lindesmith L; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Watanabe J; California National Primate Research Center, University of California at Davis, Davis, California 95616, USA.
  • Usachenko JL; California National Primate Research Center, University of California at Davis, Davis, California 95616, USA.
  • Hopkins L; California National Primate Research Center, University of California at Davis, Davis, California 95616, USA.
  • Immareddy R; California National Primate Research Center, University of California at Davis, Davis, California 95616, USA.
  • Lakshmanappa YS; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, California 95616, USA.
  • Elizaldi SR; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, California 95616, USA.
  • Roh JW; Graduate Group in Immunology, University of California, Davis, California 95616, USA.
  • Sammak RL; Center for Immunology and Infectious Diseases, University of California at Davis, Davis, California 95616, USA.
  • Pollard RE; Graduate Group in Immunology, University of California, Davis, California 95616, USA.
  • Yee JL; California National Primate Research Center, University of California at Davis, Davis, California 95616, USA.
  • Herbek S; School of Veterinary Medicine, University of California, Davis, California 95616, USA.
  • Scobey T; California National Primate Research Center, University of California at Davis, Davis, California 95616, USA.
  • Miehlke D; Department of Pediatrics, Weill Cornell Medical College, NY, New York 10065, USA.
  • Fouda G; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Ferrari G; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Gao H; Departent of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA.
  • Shen X; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Kozlowski PA; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Montefiori D; Departent of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA.
  • Hudgens MG; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Edwards DK; Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Carfi A; Departent of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA.
  • Corbett KS; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Graham BS; Departent of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA.
  • Fox CB; Departent of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA.
  • Tomai M; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
  • Iyer SS; Departent of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA.
  • Baric R; Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Reader R; Moderna, Inc., Cambridge, MA 02139, USA.
  • Dittmer DP; Moderna, Inc., Cambridge, MA 02139, USA.
  • Van Rompay KKA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Permar SR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA.
  • De Paris K; Access to Advanced Health Institute, Seattle, Washington 98102, USA.
Sci Transl Med ; : eadd6383, 2022 Dec 01.
Article in English | MEDLINE | ID: covidwho-2272197
ABSTRACT
The U.S. Food and Drug Administration only gave emergency-use-authorization of the BNT162b2 and the mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet, questions regarding the durability of vaccine efficacy, especially against emerging variants, in this age group remain. We demonstrated previously that a two-dose regimen of stabilized prefusion Washington SARS-CoV-2 S-2P spike (S) protein encoded by mRNA encapsulated in lipid nanoparticles (mRNA-LNP) or purified S-2P mixed with 3 M-052, a synthetic toll-like receptor (TLR) 7/8 agonist, in a squalene emulsion (Protein+3 M-052-SE) was safe and immunogenic in infant rhesus macaques. Here, we demonstrate that broadly neutralizing and spike-binding antibodies against variants of concern (VOC), as well as T cell responses, persisted for 12 months. At one year, corresponding to human toddler age, we challenged vaccinated rhesus macaques and age-matched non-vaccinated controls intranasally and intratracheally with a high-dose of heterologous SARS-CoV-2 B.1.617.2 (Delta). Seven of eight control rhesus macaques exhibited severe interstitial pneumonia and high virus replication in the upper and lower respiratory tract. In contrast, vaccinated rhesus macaques had faster viral clearance with mild to no pneumonia. Neutralizing and binding antibody responses to the B.1.617.2 variant at the day of challenge correlated with lung pathology and reduced virus replication. Overall, the Protein+3 M-052-SE vaccine provided superior protection to the mRNA-LNP vaccine, emphasizing opportunities for optimization of current vaccine platforms. Notably, the observed efficacy of both vaccines one year after vaccination supports the implementation of an early life SARS-CoV-2 vaccine.

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Sci Transl Med Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Scitranslmed.add6383

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Sci Transl Med Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Scitranslmed.add6383