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Kikuchi-Fujimoto disease following SARS-CoV-2 vaccination.
Ikeda, Kohsuke; Kakehi, Eiichi; Adachi, Seiji; Kotani, Kazuhiko.
  • Ikeda K; Department of General Medicine, Tottori Municipal Hospital, Tottori, Japan.
  • Kakehi E; Department of General Medicine, Tottori Municipal Hospital, Tottori, Japan openwater_swimming5933@yahoo.co.jp.
  • Adachi S; Department of General Medicine, Tottori Municipal Hospital, Tottori, Japan.
  • Kotani K; Division of Community and Family Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
BMJ Case Rep ; 15(11)2022 Nov 22.
Article in English | MEDLINE | ID: covidwho-2137567
ABSTRACT
A previously healthy Japanese woman in her 20s was admitted to our hospital with a 2-week history of fever (39.0°C) and a 1-week history of painful cervical lymphadenopathy. The day before fever onset, she had received her first Pfizer-BioNTech SARS-CoV-2 vaccine in her left arm. She had previously been treated with empirical antibiotics with no improvement. Physical examination revealed painful lymphadenopathy in both posterior cervical regions. CT showed symmetrical lymphadenopathies in the neck, supraclavicular, axillary and inguinal regions as well as hepatosplenomegaly. We suspected lymphoma and performed a lymph node biopsy in the right inguinal region, which revealed necrotising histiocytic lymphadenitis. The patient was, therefore, diagnosed with Kikuchi-Fujimoto disease (KFD). She improved after the corticosteroid therapy. This report highlights the importance of including KFD as a differential diagnosis of lymphadenopathy after SARS-CoV-2 vaccination. Additionally, lymph node biopsy is helpful for diagnosing KFD because it rules out other entities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Histiocytic Necrotizing Lymphadenitis / Lymphadenopathy / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid / Vaccines Limits: Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2022-250601

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Histiocytic Necrotizing Lymphadenitis / Lymphadenopathy / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid / Vaccines Limits: Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2022-250601