Effects of hypoxia on respiratory diseases: perspective view of epithelial ion transport.
Am J Physiol Lung Cell Mol Physiol
; 323(3): L240-L250, 2022 09 01.
Article
in English
| MEDLINE | ID: covidwho-2138198
ABSTRACT
The balance of gas exchange and lung ventilation is essential for the maintenance of body homeostasis. There are many ion channels and transporters in respiratory epithelial cells, including epithelial sodium channel, Na,K-ATPase, cystic fibrosis transmembrane conductance regulator, and some transporters. These ion channels/transporters maintain the capacity of liquid layer on the surface of respiratory epithelial cells and provide an immune barrier for the respiratory system to clear off foreign pathogens. However, in some harmful external environments and/or pathological conditions, the respiratory epithelium is prone to hypoxia, which would destroy the ion transport function of the epithelium and unbalance the homeostasis of internal environment, triggering a series of pathological reactions. Many respiratory diseases associated with hypoxia manifest an increased expression of hypoxia-inducible factor-1, which mediates the integrity of the epithelial barrier and affects epithelial ion transport function. It is important to study the relationship between hypoxia and ion transport function, whereas the mechanism of hypoxia-induced ion transport dysfunction in respiratory diseases is not clear. This review focuses on the relationship between hypoxia and respiratory diseases, as well as dysfunction of ion transport and tight junctions in respiratory epithelial cells under hypoxia.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiration Disorders
/
Sodium-Potassium-Exchanging ATPase
Type of study:
Experimental Studies
Limits:
Humans
Language:
English
Journal:
Am J Physiol Lung Cell Mol Physiol
Journal subject:
Molecular Biology
/
Physiology
Year:
2022
Document Type:
Article
Affiliation country:
Ajplung.00065.2022
Similar
MEDLINE
...
LILACS
LIS